Publications by authors named "N Hafez"
Brinzolamide (BRZ) is an antiglaucoma drug also used by athletes for doping purposes; therefore, it is prohibited by the World Anti-Doping Agency. Consequently, the presence of BRZ or its metabolites in athletes' urine constitutes a violation of anti-doping rules. The current work presents a novel electrochemical method that assesses the effectiveness of mercury oxide nanoparticles (HgO-NPs) and a mercuric chloride-1,10-phenanthroline complex (HgCl-Phen complex) as sensors for BRZ analysis.
View Article and Find Full Text PDFScreening of voice and vocal tract changes in professional wind instrument players.
Eur Arch Otorhinolaryngol
September 2024
Purpose: Playing wind instruments is a strenuous task on the larynx, predisposing players to voice disorders. This study aims to evaluate potential vocal symptoms and vocal tract alterations in professional wind instrumentalists.
Methods: In this cross-sectional study, 26 male military subjects were interviewed, completed the voice handicap index (VHI) -10 questionnaire, and subjected to auditory-perceptual assessment, neck examination, rigid laryngostroboscopy and flexible nasofiberoscopy both before and during instrument playing.
Article Synopsis
- In advanced biliary tract cancer (BTC), there is a need for effective second-line treatments due to the disease's molecular diversity; a new target has been identified that appears in about 5-8% of cases.* -
- An analysis of ongoing trials tested brigimadlin, a potent oral drug targeting MDM2-p53, alone and in combination with other therapies on 12 BTC patients, leading to significant responses.* -
- The results showed that brigimadlin had a good safety profile and resulted in anti-tumor activity, especially in patients with the specific genetic amplification, necessitating further research.*
Purpose: The poly (ADP-ribose) polymerase inhibitor niraparib is indicated as maintenance treatment in patients with certain subtypes of advanced ovarian cancer, and is being investigated in patients with other solid tumors. Niraparib is available in 100-mg capsules with a starting dosage of 200 or 300 mg/d. This study assessed the relative bioavailability (BA) and bioequivalence (BE) between a 1 × 300-mg tablet relative to 3 × 100-mg niraparib capsules.
View Article and Find Full Text PDFBackground: Sleep difficulties following a cerebrovascular stroke are an interesting topic in the scientific community. Following a brain ischemic insult, a variety of sleep problems can occur.
Aim Of Work: To study the sleep architecture following stroke and to identify the impact of site, size and severity of ischemic cerebrovascular troke on sleep microstructure.