Re-Examination Characterization and Screening of Stripe Rust Resistance Gene of Wheat Gene Family Based on the Transcriptome in Xinchun 32.

Pathogenesis-related protein-1 (PR1) encodes a water-soluble protein produced in plants after pathogen infection or abiotic stimulation. It plays a crucial role in plant-induced resistance by attacking pathogens, degrading cell wall macromolecules and pathogen toxins, and inhibiting the binding of viral coat proteins to plant receptor molecules. Compared to model plants, the mechanism of action of PR1 in wheat remains underexplored.

Breaking barriers in targeted Therapy: Advancing exosome Isolation, Engineering, and imaging.

Exosomes have emerged as promising tools for targeted drug delivery in biomedical applications and medicine. This review delves into the scientific advancements, challenges, and future prospects specifically associated with these technologies. In this work, we trace the research milestones that led to the discovery and characterization of exosomes and extracellular vesicles, and discuss strategies for optimizing the synthetic yield and the loading of these particles with various therapeutics.

Mapping subcortical brain lesions, behavioral and acoustic analysis for early assessment of subacute stroke patients with dysarthria.

Introduction: Dysarthria is a motor speech disorder frequently associated with subcortical damage. However, the precise roles of the subcortical nuclei, particularly the basal ganglia and thalamus, in the speech production process remain poorly understood.

Methods: The present study aimed to better understand their roles by mapping neuroimaging, behavioral, and speech data obtained from subacute stroke patients with subcortical lesions.

The conformational landscape of human transthyretin revealed by cryo-EM.

Transthyretin (TTR) is a natively tetrameric thyroxine transporter in blood and cerebrospinal fluid whose misfolding and aggregation causes TTR amyloidosis. A rational drug design campaign identified the small molecule tafamidis (Vyndamax) as a stabilizer of the native TTR fold, and this aggregation inhibitor is regulatory agency approved for the treatment of TTR amyloidosis. Here we used cryo-EM to investigate the conformational landscape of this 55 kDa tetramer in the absence and presence of one or two ligands, revealing inherent asymmetries in the tetrameric architecture and previously unobserved conformational states.

Photocatalytic upcycling of polylactic acid to alanine by sulfur vacancy-rich cadmium sulfide.

Photocatalytic conversion has emerged as a promising strategy for harnessing renewable solar energy in the valorization of plastic waste. However, research on the photocatalytic transformation of plastics into valuable nitrogen-containing chemicals remains limited. In this study, we present a visible-light-driven pathway for the conversion of polylactic acid (PLA) into alanine under mild conditions.