Publications by authors named "N H Shamsudin"
G protein-coupled receptors (GPCRs) are essential cell surface proteins involved in transducing extracellular signals into intracellular responses, regulating various physiological processes. This study validated the use of the Tango assay, a sensitive method for detecting GPCR activation, in Schneider 2 (S2) cells, focusing on the human Dopamine Receptor D4 (DRD4). Plasmids encoding the LexA-tagged human DRD4 receptor and a luciferase reporter were co-transfected into S2 cells and stimulated with dopamine.
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- Monoamine oxidase (MAO) is important for breaking down neurotransmitters and is a potential target for treating neurodegenerative diseases like depression and Alzheimer's.
- The study examined chromone-based compounds to see how effectively they inhibit MAO-A and MAO-B, identifying several promising derivatives through molecular docking techniques.
- A quantitative structure-activity relationship (QSAR) model was developed to predict the effectiveness of these compounds, showing strong validation with experimental data and highlighting key molecular features that enhance their inhibitory effects.
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- Adamantinomatous craniopharyngioma (ACP) is a rare, benign brain tumor primarily affecting adolescents and older adults, classified as a Grade 1 central nervous system tumor by the WHO.
- An 18-year-old Malaysian female with a six-year history of nosebleeds and nasal blockage presented a rare case of ACP, as it was located in the sinonasal region rather than the typical sellar and suprasellar areas.
- The tumor's unique position was identified through CT and MRI imaging and confirmed by histopathological analysis, prompting a discussion on its atypical presentation and the challenges involved in diagnosis and treatment.
Chromones are promising for anticancer drug development. 12 chromone-based compounds were synthesized and tested against cancer cell lines. Compound showed the highest cytotoxicity (LC 3.
View Article and Find Full Text PDFThe anti-inflammatory and immunosuppressive activities of plant secondary metabolites are due to their diverse mechanisms of action against multifarious molecular targets such as modulation of the complex immune system associated with rheumatoid arthritis (RA). This review discussed and critically analyzed the potent anti-inflammatory and immunosuppressive effects of several phytochemicals and their underlying mechanisms in association with RA in experimental studies, including preliminary clinical studies of some of them. A wide range of phytochemicals including phenols, flavonoids, chalcones, xanthones, terpenoids, alkaloids, and glycosides have shown significant immunosuppressive and anti-inflammatory activities in experimental RA models and a few have undergone clinical trials for their efficacy and safety in reducing RA symptoms and improve patient outcomes.
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