Publications by authors named "N H S Deghaide"
Article Synopsis
- CMV retinochoroiditis (CMV-R) is a leading cause of blindness in AIDS patients, and this study focuses on the HLA-G gene's 3'UTR region in relation to the disease risk.
- Researchers compared DNA samples from AIDS patients with CMV-R and those without, discovering certain HLA-G gene variations linked to an increased risk of developing CMV-R.
- Specifically, the study found an association between certain alleles and haplotypes of the HLA-G 3'UTR and CMV-R, suggesting a potential role in immune response modulation in the context of HIV-related immunosuppression.
Purpose: Since cytomegalovirus retinitis (CR) is an important cause of visual impairment among AIDS patients and alleles have been associated with AIDS disease outcome, we typed locus in patients with AIDS exhibiting or not CR.
Methods: Three groups of individuals were studied: (i) 49 patients with AIDS and CR (Group I), (ii) 161 patients with AIDS without CR (Group II), and (iii) 202 healthy HIV-negative individuals (Group III). typing was performed using commercial kits.
The HLA-G 14-base pair deletion allele and the deletion/deletion genotype are associated with persistent HBe antigenemia in chronic hepatis B infection.
Hum Immunol
February 2017
Background And Aims: HLA-G has well-recognized immunomodulatory properties, and this molecule is frequently expressed in the livers of hepatitis B virus (HBV)-infected patients. Because the HLA-G 14 bp-insertion/deletion polymorphism (rs371194629) has been associated with the magnitude of HLA-G expression, we evaluated this polymorphism in the recognized evolutionary forms of chronic HBV infection.
Methods: We studied 196 chronic HBV-infected patients (118 HBeAg-negative chronic hepatitis, 53 HBeAg-positive chronic hepatitis and 25 inactive carriers exhibiting low levels of serum HBVDNA and persistently normal ALT levels), and 202 healthy individuals.
Genetic factors, particularly those concerning HLA class II, have been associated with the pathogenesis of pemphigus. Taking advantage of an area where pemphigus foliaceus (PF) and pemphigus vulgaris (PV) are prevalent in the northeastern region of the state of São Paulo, Southeastern Brazil, we have studied the HLA class I (A, B and C) and class II (DRB1 and DQA1/DQB1) profiles in 86 and 83 patients with PF and PV, respectively, as compared with 1592 controls from the same region. Among all the HLA alleles described herein, the more prevalent susceptibility alleles for PF were HLA-A*11, 33, -B*14; -DRB1*01:01, *01:02; -DQA1*01:02; and -DQB1*05:01.
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