Does swallow rehabilitation improve recovery of swallow function after treatment for advanced head and neck cancer.

This study aimed to assess the prevalence, severity, and progression of swallowing impairments in head and neck cancer (HNC) patients before and after treatment, using videofluoroscopy with the Modified Barium Swallow Impairment Profile (MBSImP) protocol. We retrospect survey 90 HNC patients was divided into rehabilitation (receiving swallowing rehabilitation) and non-rehabilitation groups. All participants underwent a videofluoroscopic swallowing study with MBSImP, the Penetration-Aspiration Scale (PAS), and the Swallowing Performance Status (SPS) scale, along with assessments using the EAT-10 and Functional Oral Intake Scale (FOIS) at baseline, and at 1 and 3 months post-treatment.

Mst1 knockout and Nrf2 activation alleviate diabetic cardiomyopathy pathogenesis through autophagy modulation in type 2 diabetic mice.

Diabetic cardiomyopathy (DCM) is a myocardial disorder resulting from glucose metabolism dysfunction, leading to structural and functional heart abnormalities independent of common cardiovascular conditions. This study explores the impact of Mammalian Sterile20-like Kinase 1 (Mst1) and Nuclear Factor E2-Related Factor 2 (Nrf2) pathways on autophagy in type 2 diabetic mice. By employing Mst1 knockout and Nrf2 activation, improvements in cardiac function reduced myocardial fibrosis, and decreased cardiomyocyte apoptosis was observed, with enhanced autophagy noted in Mst1 knockout mice further augmented by Nrf2 activation.

Dysregulation of Calcium Homeostasis: An Important Factor Leading to Ferroptosis in Cardiovascular Diseases.

Cardiovascular disease is a circulatory system disease involving the heart and blood vessels, which is one of the main causes of human health loss and even life-threatening. Ca is an important signal molecule. Free calcium ions in the cytoplasm are involved in various physiological and biochemical reactions of cells.

EUFormer: Learning Driven 3D Spine Deformity Assessment with Orthogonal Optical Images.

In clinical settings, the screening, diagnosis, and monitoring of adolescent idiopathic scoliosis (AIS) typically involve physical or radiographic examinations. However, physical examinations are subjective, while radiographic examinations expose patients to harmful radiation. Consequently, we propose a pipeline that can accurately determine scoliosis severity.

RASpine: Regional Attention Lateral Spinal Segmentation based on Anatomical Prior Knowledge.

In the clinical diagnosis and treatment of spinal disorders, segmenting the spine from X-ray images provides clear visualization of the spinal structure and morphology. However, while existing spine segmentation methods perform well on anteroposterior X-ray images, their performance is poor on lateral X-rays. This is mainly due to the low contrast and severe occlusion of the thoracic vertebrae on lateral X-rays, resulting in overlapping vertebrae in segmentation results.