Publications by authors named "N H Chia"
Background: COVID-19-related social restrictions provided an opportunity to evaluate the impact of social isolation on Parkinson's disease.
Objective: This study aimed to explore changes in social isolation and their associations with PD symptoms using the Lubben Social Network Scale-Revised (LSNS-R).
Methods: Data from 80 participants of the Early Parkinson's Disease Longitudinal Singapore cohort were collected from April 2019 to April 2023, covering the periods before and after the imposition of COVID-19 restrictions.
DNMT3A and TET2 are epigenetic regulator genes commonly mutated in age-related clonal hematopoiesis (CH). Despite having opposed epigenetic functions, these mutations are associated with increased all-cause mortality and a low risk for progression to hematological neoplasms. While individual impacts on the epigenome have been described using different model systems, the phenotypic complexity in humans remains to be elucidated.
View Article and Find Full Text PDFBackground And Aims: HCC recurrence frequently occurs after curative surgery. Histological microvascular invasion (MVI) predicts recurrence but cannot provide preoperative prognostication, whereas clinical prediction scores have variable performances.
Approach And Results: Recurr-NET, a multimodal multiphasic residual-network random survival forest deep-learning model incorporating preoperative CT and clinical parameters, was developed to predict HCC recurrence.
Article Synopsis
- The study aimed to analyze how motor, non-motor, and cognitive abilities progress in early-stage Parkinson's Disease (PD) patients, particularly those with Mild Cognitive Impairment (MCI).
- Researchers assessed 205 PD patients over five years, comparing those with MCI to those with normal cognition, using various scoring methods to evaluate disease progression.
- Results showed that PD-MCI patients experienced faster declines in motor functions and cognitive domains, particularly in visuospatial and perceptual abilities, highlighting the need for tailored management strategies for these patients.
Background & Aims: Combined F-fluorodeoxyglucose (FDG) and C-acetate (dual-tracer) positron-emission tomography/computed tomography (PET/CT) is being increasingly performed for the management of hepatocellular carcinoma (HCC), although its role is not well defined. Therefore, we evaluated its effectiveness in (i) staging, (ii) characterization of indeterminate lesions on conventional imaging, and (iii) detection of HCC in patients with unexplained elevations in serum alpha-fetoprotein (AFP) levels.
Methods: We retrospectively assessed 525 consecutive patients from three tertiary centers between 2014 and 2020.