Publications by authors named "N H Carey"
Article Synopsis
- Axon myelination plays a crucial role in refining neuronal circuits by adjusting myelin sheath patterns across different axon types, but the coordination behind this process is still not fully understood.
- Recent studies suggest that neuronal activity and the release of vesicles can stimulate the formation of myelin, and oligodendrocytes express proteins that may aid in their interaction with axons for proper myelination.
- In larval zebrafish, the protein Gephyrin (Gphn) appears to selectively enhance myelin formation on GABAergic axons, with findings showing that in Gphn-deficient larvae, there were longer myelin sheaths on GABAergic axons
Article Synopsis
- TGF-β is a crucial protein involved in development and immunity, usually expressed in a latent form associated with its prodomain and presented on immune cells via GARP.
- Recent findings indicate that TGF-β can signal without needing to fully dissociate from its latent form, challenging existing beliefs.
- New research using advanced microscopy shows that the binding of integrin αvβ8 can alter the structure of latent TGF-β, allowing it to activate signaling pathways without being released, and this mechanism may apply to other similar receptor/ligand systems.
Background: Recent advances in the development of biomarker-directed therapy and immunotherapy, for advanced and metastatic gastric cancers, have the potential to improve survival and quality of life. Much attention has been directed towards second- and later-line treatments, and the landscape here is evolving rapidly. However, uncertainty in relative effectiveness, high costs and uncertainty in cost effectiveness represent challenges for decision makers.
View Article and Find Full Text PDFReporting guidelines for terrestrial respirometry: Building openness, transparency of metabolic rate and evaporative water loss data.
Comp Biochem Physiol A Mol Integr Physiol
October 2024
Respirometry is an important tool for understanding whole-animal energy and water balance in relation to the environment. Consequently, the growing number of studies using respirometry over the last decade warrants reliable reporting and data sharing for effective dissemination and research synthesis. We provide a checklist guideline on five key sections to facilitate the transparency, reproducibility, and replicability of respirometry studies: 1) materials, set up, plumbing, 2) subject conditions/maintenance, 3) measurement conditions, 4) data processing, and 5) data reporting and statistics, each with explanations and example studies.
View Article and Find Full Text PDFIntroduction: Non-medical professionals in the United Kingdom (UK) have been granted prescribing rights to improve patient care quality and cost-effectiveness. There is limited evidence on how therapeutic radiographer prescribers have impacted medicine management or patient services.
Methods: An online survey was conducted amongst non-medical prescribing therapeutic radiographers in the UK between 2019 and 2022.