Bioavailability of spiramycin and lincomycin after oral administration to fed and fasted pigs.

The disposition of spiramycin and lincomycin was measured after intravenous (i.v.) and oral (p.

Bioavailability of enrofloxacin after oral administration to fed and fasted pigs.

The disposition of enrofloxacin was measured after intravenous and oral administration to pigs. Eight clinically healthy pigs weighing 25 to 40 kg received a dose of 5 mg/kg intravenously and 10 mg/kg orally in both a fasted and a fed condition in a three-way cross-over design. Enrofloxacin was present in plasma for up to 72 hr after both intravenous and oral administration to fasted as well as fed pigs.

Bioavailability of oxytetracycline, tetracycline and chlortetracycline after oral administration to fed and fasted pigs.

The disposition of oxytetracycline (OTC), tetracycline (TC) and chlortetracycline (CTC) was measured after intravenous and oral administration to pigs. Eighteen healthy pigs (six for each compound) weighing 22-43 kg received a dose of 10 mg/kg intravenously, and 45 mg/kg (OTC and TC) or 40 mg/kg (CTC) orally in both a fasted and a fed condition in a three-way crossover design. The three tetracyclines were present in plasma up to 30 hours after intravenous and after oral administration to fasted as well as fed pigs.

A method for in vitro determination of the acaricidal effect of ivermectin using Sarcoptes scabiei var. suis as test organism.

An in vitro assay for the acaricidal effect of ivermectin is described. The test is based on the migration ability and survival of Sarcoptes scabiei var. suis mites on the surface of agar gels containing the acaricide.

Disposition of parathion after dermal application in pigs.

Pharmacokinetic parameters of parathion were studied in pigs after intravenous (i.v.) and dermal administration of unlabelled and 14C-parathion.