Chimeric Peptide-Engineered Polyprodrug Enhances Cytotoxic T Cell Response by Inducing Immunogenic Cell Death and Upregulating Major Histocompatibility Complex Class I.

Tumor-specific cytotoxic T cell immunity is critically dependent on effective antigen presentation and sustained signal transduction. However, this immune response is frequently compromised by the inherently low immunogenicity of breast cancer and the deficiency in major histocompatibility complex class I (MHC-I) expression. Herein, a chimeric peptide-engineered stoichiometric polyprodrug (PDPP) is fabricated to potentiate the cytotoxic T cell response, characterized by a high drug loading capacity and precise stoichiometric drug ratio, of which the immunogenic cell death (ICD) inducer of protoporphyrin IX (PpIX) and the epigenetic drug of decitabine (DAC) are condensed into a polyprodrug called PpIX-DAC.

Genome-wide association study of sucrose content in vegetable soybean.

Background: Vegetable soybean is an important legume vegetable. High sucrose content is a significant quality characteristic of vegetable soybean that influences consumers' taste. However, the genetic basis of sucrose content in vegetable soybean is currently unclear.

On-Chip Photonic Simulating Band Structures toward Arbitrary-Range Coupled Frequency Lattices.

Photonic simulators are increasingly used to study physical systems for their affluent manipulable degrees of freedom. The advent of photonic chips offers a promising path towards compact and configurable simulators. Thin-film lithium niobate chips are particularly well suited for this purpose due to the high electro-optic coefficient, which allows for the creation of lattices in the frequency domain.

Polar Histogram Visualization of Acute Stress Disorder Scale Scores for Comprehensive Clinical Assessment.

The Acute Stress Disorder Scale (ASDS) is crucial for assessing acute stress disorder (ASD), especially in high-stress environments like Intensive Care Units (ICUs). Traditional methods struggle to interpret all 19 ASDS variables simultaneously. This study introduces a novel polar histogram visualization approach to enhance ASDS score analysis, focusing on elderly ICU caregivers.

Improving stability and bioavailability of ACNs based on Gellan gum-whey protein isolate nanocomplexes.

Blueberry anthocyanins (ACNs) have been widely applied in the food industry and medicine due to their numerous beneficial properties. However, the stability of ACNs is extremely poor. This study aimed to develop a delivery system for ACNs using nanocomplexes prepared from gellan gum (GG) and whey protein isolate (WPI) via Maillard reaction.