A Novel Rare Missense Variation of the Gene: Evidencesof Implication in Crohn's Disease.

The gene, involved in innate immune responses to bacterial peptidoglycan, has been found to be closely associated with Crohn's Disease (CD), with an Odds Ratio ranging from 3⁻36. Families with three or more CD-affected members were related to a high frequency of gene variations, such as R702W, G908R, and 1007fs, and were reported in the EPIMAD Registry. However, some rare CD multiplex families were described without identification of common linked-to-disease variations.

Post-operative complications in elderly onset inflammatory bowel disease: a population-based study.

Background: IBD diagnosed after the age of 60 is increasing. Data on post-operative complications in elderly onset IBD are scarce.

Aim: To describe the incidence of and factors associated with post-operative complications in elderly onset IBD, diagnosed after the age of 60.

Validation of the Inflammatory Bowel Disease Disability Index in a population-based cohort.

Background: IBDs are chronic destructive disorders that negatively affect the functional status of patients. Recently, the Inflammatory Bowel Disease Disability Index (IBD-DI) was developed according to standard WHO processes. The aims of the current study were to validate the IBD-DI in an independent patient cohort, to develop an index-specific scoring system and to describe the disability status of a well-defined population-based cohort of French patients with IBD.