Publications by authors named "N Gronich"
Article Synopsis
- The study aimed to analyze the prevalence and distribution of common chronic conditions and cancers among a large population to improve patient enrollment in clinical trials and the relevance of results.
- Data collected from over 4.6 million people revealed that obesity, hypertension, and diabetes were the most prevalent conditions, with significant age and sex variations in their distributions.
- The research found that the five most common active cancers were breast, prostate, colon/rectal, lymphoma, and melanoma, with cancer prevalence increasing with age, highlighting differences between men and women, especially in lung cancer cases.
Introduction: Biological and scarce epidemiological evidence suggested that phosphodiesterase-5 inhibitors (PDE5i) might reduce dementia risk. We aimed to examine the association between PDE5i and dementia using real-world data.
Methods: Two retrospective cohorts within the database of Clalit, the largest healthcare provider in Israel (2005-2023), were studied.
Medications and Acute Hemolysis in G6PD-Deficient Patients - A Real-World Study.
Clin Pharmacol Ther
December 2024
Many drug labels contain precautions of use in G6PD-deficient patients due to hemolytic concerns, but much of this is based on scarce clinical, epidemiological, or structural data. In this real-world study, we aimed to examine if the administration of presumably risky medications for G6PD-deficient patients was followed by hemolysis. The study is based on data from Clalit Health Services database that provides inclusive health care for more than half of the Israeli population (~ 4.
View Article and Find Full Text PDFMost drugs have not been evaluated in the older population. Recognizing physiological alterations associated with changes in drug disposition and with the ultimate effect, especially in central nervous system-acting drugs, is fundamental. While considering pharmacokinetics, it should be noted that the absorption of most drugs from the gastrointestinal tract does not change in advanced age.
View Article and Find Full Text PDFBackground And Objectives: Existing data regarding occurrence of Guillain-Barré syndrome (GBS) after coronavirus disease 2019 (COVID-19) infection and vaccination are inconclusive. We aimed to assess the association between GBS and both severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and COVID-19 vaccine.
Methods: We conducted a nested case-control study in a cohort of 3,193,951 patients aged 16 years or older, without a diagnosis of prior GBS, from the largest health care provider in Israel.