Xist RNA initiates X inactivation as it spreads in cis across the chromosome. Here, we reveal a biophysical basis for its cis-limited diffusion. Xist RNA and HNRNPK together drive a liquid-liquid phase separation (LLPS) that encapsulates the chromosome.
View Article and Find Full Text PDFWe combine measurements of galaxy velocities from galaxy surveys with measurements of the Weyl potential from the Dark Energy Survey to test the consistency of general relativity at cosmological scales. Taking the ratio of two model-independent observables-the growth rate of structure and the Weyl potential-we obtain new measurements of the E_{G} statistic with precision of 6.0-11.
View Article and Find Full Text PDFThe smooth emergence of shear elasticity is a hallmark of the liquid to glass transition. In a liquid, viscous stresses arise from local structural rearrangements. In the solid, Eshelby has shown that stresses around an inclusion decay as a power law r-D, where D is the dimension of the system.
View Article and Find Full Text PDFThe anterolateral ligament has gained attention as a secondary stabilizer of anterolateral rotatory stability of the knee. This has had implications among sports medicine specialists as an adjunct procedure with anterior cruciate ligament reconstruction to improve stability. As indications have evolved for its use as an anterior cruciate ligament reconstruction augment, so have the techniques for reconstruction.
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