Publications by authors named "N Gozzard"
Article Synopsis
- Initiation of adaptive immunity involves distinct cell populations migrating to specific sites, but tracking these movements has been challenging due to limitations in current methods.
- Researchers utilized photo-convertible transgenic mice to gain insights into the cell populations that leave the site of skin priming and enter the draining lymph node, revealing that most migratory cells were recruited to the priming site during inflammation.
- The study provides a comprehensive map of cell dynamics and characteristics during immune response activation, highlighting important cell types like dendritic cells and T cells, and offering valuable information for improving immunotherapy strategies in autoimmunity and vaccination.
Efficacy of an Inhaled IL-13 Antibody Fragment in a Model of Chronic Asthma.
Am J Respir Crit Care Med
September 2018
Rationale: IL-13 is an important cytokine implicated in the pathogenesis of allergic asthma and is an attractive target for an inhaled therapeutic.
Objective: To investigate the efficacy of CDP7766, a nebulized inhaled anti-IL-13 monoclonal antibody Fab fragment, in a model of allergic asthma in cynomolgus macaques naturally sensitized to Ascaris suum.
Methods: CDP7766 was nebulized using a vibrating-membrane nebulizer on the basis of eFlow technology.
Collaboration can be challenging; nevertheless, the emerging successes of large, multi-partner, multi-national cooperatives and research networks in the biomedical sector have sustained the appetite of academics and industry partners for developing and fostering new research consortia. This model has percolated down to national funding agencies across the globe, leading to funding for projects that aim to realise the true potential of genomic medicine in the 21st century and to reap the rewards of 'big data'. In this Perspectives article, the experiences of the RA-MAP consortium, a group of more than 140 individuals affiliated with 21 academic and industry organizations that are focused on making genomic medicine in rheumatoid arthritis a reality are described.
View Article and Find Full Text PDFManagement of severe asthma remains a challenge despite treatment with glucocorticosteroid therapy. The majority of studies investigating disease mechanisms in treatment-resistant severe asthma have previously focused on the large central airways, with very few utilizing transcriptomic approaches. The small peripheral airways, which comprise the majority of the airway surface area, remain an unexplored area in severe asthma and were targeted for global epithelial gene expression profiling in this study.
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