Cyclosporin A stimulates apical Na+/H+ exchange in LLC-PK1/PKE20 proximal tubular cells.

Cyclosporin A (CyA) causes renal Na(+) retention which may lead to arterial hypertension. The apical Na(+)/H(+) exchanger (NHE3) is responsible for bulk proximal tubular Na(+) reabsorption. The aim of this study was to investigate the effects of CyA on the NHE3 of polarized proximal tubular cells to evaluate cellular mechanisms of CyA-associated arterial hypertension.

Chloroacetaldehyde- and acrolein-induced death of human proximal tubule cells.

Ifosfamide (ifo) is a commonly used drug in chemotherapy. It is metabolized to acrolein (acro) and chloroacetaldehyde (CAA), which are thought to be responsible for renal side effects. We studied the effects of ifo and cyclophosphamide (cyclo) as well as their metabolites, acro and CAA, on cellular protein content, necrosis, apoptosis and cytosolic calcium concentration using a human proximal tubule cell line.

Disturbed Ca2+-signaling by chloroacetaldehyde: a possible cause for chronic ifosfamide nephrotoxicity.

Background: Renal damage following chemotherapy with ifosfamide is attributed to the metabolic activation of the drug and the generation of chloroacetaldehyde (CAA). Little is known about the mechanism by which CAA impairs renal function. In this study the effect of CAA on intracellular Ca(2+) homeostasis in human renal proximal tubule cells (RPTEC) in primary culture was investigated.

Membranous nephropathy associated with familial chronic ulcerative colitis in a 12-year-old girl.

Glomerulonephritis is a rare complication in patients with inflammatory bowel disease. We report a case of membranous nephropathy (MN) in a 12.6-year-old girl with chronic ulcerative colitis.

[Fetal and neonatal kidney function. Implications for fetal urinary tract abnormalities].

High-resolution sonography provides the opportunity for prenatal detection of fetal anomalies of the urinary tract. In view of various options of prenatal urinary diversion to alleviate obstruction, it has become a scientific goal to measure fetal renal function and to determine the prognosis of urinary tract malformations. The article outlines the accumulated knowledge of the development of fetal renal function and the diagnostic possibilities offered by sonography and by laboratory test with focus on the chemistry of the amniotic fluid.