Predictive biomarkers candidates for patients with metastatic colorectal cancer treated with bevacizumab-containing regimen.

Bevacizumab was the first molecular-targeted antiangiogenic therapy approved for the treatment of metastatic colorectal cancer. Until now, there are no predictive biomarkers available to decide the prescription of bevacizumab in patients with colorectal cancer. The purposes of this review were to provide a critical appraisal of the evidence and to identify possible predictive genetic biomarkers.

Equity in access to high cost drugs in Uruguay.

Objective: The aim of this study was to determine the equity in access to high cost oncology medicines reimbursed by the Uruguayan National Health System. Also, were determined the causes of access inequities.

Methods: Different levels of access were determined by crossing epidemiological and reimbursement data with geographical distribution and number of Health System users.

[Not Available].

Objective: To support an evidence-based decision regarding the inclusion of the anti TNF's adalimumab, etanercept or infliximab to the National Formulary of Uruguay for the treatment of psoriatic arthritis, in patients who did not respond to first-line treatment.

Methods: We perform a cost-utility evaluation using a Markov model, to estimate the incremental costs and quality-adjusted life years (QALY) gained with each of these biologic drugs compared with palliative care only. The model considered the perspective of the National Health System, with a time horizon of 40 years.

Rituximab and tocilizumab for the treatment of rheumatoid arthritis.

Objectives: The aim of this study was to evaluate the efficacy and safety of rituximab and tocilizumab compared with adalimumab, etanercept, and infliximab, in patients with rheumatoid arthritis not responding to first-line treatment, and to compare the efficacy and safety of rituximab versus tocilizumab in patients not responding to anti-tumor necrosis factor α (anti-TNF) therapy.

Methods: A literature search of randomized controlled trials, controlled clinical trials, and systematic reviews was performed to evaluate efficacy and safety of rituximab and tocilizumab.

Results: Twenty-four RCTs were included in this systematic review with 6,357 participants; 3,450 treated with biological DMARD and 2,907 with standard care.

MDR-1 genotypes and quetiapine pharmacokinetics in healthy volunteers.

Background: P-glycoprotein is an efflux transporter encoded by the multidrug-resistance MDR-1 gene, which influences the absorption and excretion of a variety of drugs. The relation between quetiapine pharmacokinetics and MDR-1 genetic polymorphisms remains controversial. Therefore, the aim of the present study was to analyze the association between quetiapine plasma concentrations and MDR-1 genetic polymorphisms in a bioequivalence trial.