Publications by authors named "N Gonzales"
Article Synopsis
- This study assesses the cost-effectiveness of mobile stroke units (MSUs) compared to standard emergency medical services (EMS) for administering thrombolytics in ischemic stroke patients.
- The analysis used the incremental cost-effectiveness ratio (ICER) method to evaluate healthcare costs and quality-adjusted life years (QALYs), highlighting considerable variations based on patient disability status and treatment costs.
- Overall, while MSUs show borderline cost-effectiveness for all eligible patients, they are more favorable for patients without pre-existing disabilities, particularly when focusing on lifetime costs and stroke-specific expenses.
Background: We developed a noninvasive biomarker to quantify the rate of ventricular blood clearance in patients with intracerebral hemorrhage and extension to the ventricles-intraventricular hemorrhage.
Methods: We performed magnetic resonance imaging in 26 patients at 1, 14, 28, and 42 days of onset and measured their hematoma volume (HV), ventricular blood volume (VBV), and two diffusion metrics: fractional anisotropy (FA), and mean diffusivity (MD). The ipasilesional ventricular cerebral spinal fluid's FA and MD were associated with VBV and stroke severity scores (National Institute of Health Stroke Scale [NIHSS]).
OTX2 is a transcription factor and known driver in medulloblastoma (MB), where it is amplified in a subset of tumours and overexpressed in most cases of group 3 and group 4 MB. Here we demonstrate a noncanonical role for OTX2 in group 3 MB alternative splicing. OTX2 associates with the large assembly of splicing regulators complex through protein-protein interactions and regulates a stem cell splicing program.
View Article and Find Full Text PDFCurrent tissue engineering (TE) methods utilize chondrocytes primarily from costal or articular sources. Despite the robust mechanical properties of neocartilages sourced from these cells, the lack of elasticity and invasiveness of cell collection from these sources negatively impact clinical translation. These limitations invited the exploration of naturally elastic auricular cartilage as an alternative cell source.
View Article and Find Full Text PDFImmigration stress and maternal sensitivity in a Mexican immigrant sample: The role of parasympathetic activity and familism value.
Cultur Divers Ethnic Minor Psychol
October 2024
Objectives: The present study examined whether immigration stress was related to decreased capacities for psychophysiological stress regulation (as indexed by respiratory sinus arrhythmia [RSA]) and whether lower RSA, in turn, was related to decreased maternal sensitivity. The buffering effect of familism values was also evaluated, such that familism values were expected to minimize associations between immigration stress, RSA, and sensitivity.
Method: Data were drawn from a longitudinal study of Mexican immigrant mothers ( = 277; = 28 years).