Publications by authors named "N Golovachev"
Background: Research on traumatic brain injury (TBI) highlights the significance of counteracting its metabolic impact via exogenous fuels to support metabolism and diminish cellular damage. While ethyl pyruvate (EP) treatment shows promise in normalizing cellular metabolism and providing neuroprotection, there is a gap in understanding the precise metabolic pathways involved. Metabolomic analysis of the acute post-injury metabolic effects, with and without EP treatment, aims to deepen our knowledge by identifying and comparing the metabolite profiles, thereby illuminating the injury's effects and EP's therapeutic potential.
View Article and Find Full Text PDFMassive rotator cuff tears constitute approximately 20% of all rotator cuff tears. Poor tissue quality or significant retraction can lead to failure of the repair. The anterior rotator cuff cable is essential in transmitting force to the proximal humerus and serves as the main load-bearing structure within the supraspinatus.
View Article and Find Full Text PDFIntroduction: A meta-analysis was conducted comparing the impact of Arthroscopic debridement (AD), trapeziectomy (TRAP), and joint replacement (JR) on the change in pain scores on patients with Basilar thumb joint arthritis (BTJA).
Methods: Four databases were searched for studies presenting pain outcomes following surgical intervention for BTJA. Pain scores were reported using the Visual Analog Scale (VAS) and compared against the pre-established threshold for Minimal Clinically Important Difference (MCID) of 1.
This systematic review evaluates nonoperative treatments for trapeziometacarpal joint osteoarthritis (TMJO), a common degenerative condition in postmenopausal females causing pain, reduced mobility, and diminished grip strength. Following PRISMA guidelines, a search was conducted across PubMed, Cochrane, Embase, and MEDLINE for randomized controlled trials (RCTs) assessing pain outcomes with nonoperative interventions over at least a six-month follow-up, using the visual analog scale (VAS) for pain measurement. Eleven RCTs yielded moderate-quality evidence for the following: (1) corticosteroid (CSI) and hyaluronic acid (HA) injections exhibit comparable mean delta pain scores after six months, with CSI offering early relief at two to three weeks.
View Article and Find Full Text PDFArticle Synopsis
- Digital papillary adenocarcinoma (DPA) is a rare tumor of the eccrine sweat glands, typically appearing as a painless, gradually growing mass, with a high risk of recurrence and potential to spread.
- The case study discusses a 46-year-old male who underwent two surgical procedures for DPA on his thumb, starting with a wide local excision and followed by joint fusion and flap coverage after confirming negative margins.
- Eighteen months post-surgery, the patient was able to return to landscaping work, highlighting the possibility of preserving thumb function despite a diagnosis of soft tissue malignancy when negative margins are achieved.