Publications by authors named "N Goldfarb"
Background: Hidradenitis suppurativa (HS) affects different patient populations that require unique considerations in their management. However, no HS guidelines for these populations exist.
Objective: To provide evidence-based consensus recommendations for patients with HS in 7 special patient populations: (i) pregnancy, (ii) breastfeeding, (iii) pediatrics, (iv) malignancy, (v) tuberculosis infection, (vi) hepatitis B or C infection, and (vii) HIV disease.
Selective small molecule inhibitors for hidradenitis suppurativa: Today and tomorrow.
J Am Acad Dermatol
December 2024
Hidradenitis suppurativa (HS) is an autoinflammatory condition characterized by abscesses, inflammatory nodules, and tunnels in intertriginous sites of the body. The pathogenesis of HS involves follicular occlusion in combination with environmental, genetic, hormonal, and metabolic factors. HS lesions are characterized by an influx of neutrophils, histiocytes, B and T cells, and upregulation of proinflammatory cytokines such as tumor necrosis factor-α, interleukin-1, interleukin-17, and interferons.
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- The study focuses on differentiating perianal issues caused by hidradenitis suppurativa (HS) and perianal fistulizing inflammatory bowel disease (IBD), as they often present similar symptoms.
- A retrospective review of patient data at the Mayo Clinic identified 15 key clinical features using machine learning to help distinguish between HS and IBD cases.
- Findings revealed significant differences in symptoms, with HS patients showing more skin-related issues and IBD patients experiencing additional gastrointestinal symptoms, which may lead to better diagnosis and treatment strategies.