Publications by authors named "N Gleeson"
Article Synopsis
- The SHAPE trial showed that simple hysterectomy is just as effective as radical hysterectomy in preventing pelvic recurrence in low-risk early-stage cervical cancer, but offers better quality of life and sexual health.
- A cost-effectiveness analysis using a Markov model over 5 years found that simple hysterectomy costs less ($11,022) and provides more quality-adjusted life years (3.56 QALYs) compared to radical hysterectomy ($12,533 and 3.54 QALYs).
- The study concluded that simple hysterectomy is a better option overall due to being more cost-effective and yielding a higher quality of life post-surgery.
Article Synopsis
- The SHAPE trial studied the effects of simple hysterectomy compared to radical hysterectomy on sexual health and quality of life in women with low-risk cervical cancer.
- Participants were assessed up to 36 months after surgery using specific questionnaires to measure sexual function and overall well-being.
- Results showed that simple hysterectomy led to better sexual health outcomes and quality of life, with lower rates of sexual dysfunction and greater global health status compared to radical hysterectomy.
Background: Retrospective data suggest that the incidence of parametrial infiltration is low in patients with early-stage low-risk cervical cancer, which raises questions regarding the need for radical hysterectomy in these patients. However, data from large, randomized trials comparing outcomes of radical and simple hysterectomy are lacking.
Methods: We conducted a multicenter, randomized, noninferiority trial comparing radical hysterectomy with simple hysterectomy including lymph-node assessment in patients with low-risk cervical cancer (lesions of ≤2 cm with limited stromal invasion).
Playing-related musculoskeletal disorders (PRMDs) are common among musicians but longitudinal data on risk factors are limited. The aim of the study was to longitudinally identify the factors associated with increased risk of PRMD onset among music students enrolled in different pan-European music institutions. A further goal was to assess the occurrence of PRMDs during a 12-month period.
View Article and Find Full Text PDFAim: To generate, test and refine programme theories that emerged from a rapid realist review investigating practising UK Nurses' and Midwives' experiences of effective leadership strategies during the COVID-19 pandemic.
Background: The realist review of literature generated six tentative theories of healthful leadership practices reflecting, working with people's beliefs and values; being facilitative; multiple means of communication and; practical support. The review yielded little insight into the actual impact of the leadership approaches advocated.