Exploring hybrid models for identifying locations for active mobility pathways using real-time spatial Delphi and GANs.

The spatial planning process is considered an extremely complex system, as it comprises different variables that interrelate and interact with each other. Effectively addressing this spatial complexity necessitates a multidisciplinary approach, as unified methodologies may prove insufficient. Specifically, in urban planning, it is increasingly crucial to prioritize bike lanes, bike stations, and pedestrian zones, for functional transportation infrastructures.

Exploring the impact of mobility restrictions on the COVID-19 spreading through an agent-based approach.

Background: The recent health emergency caused by the COVID-19 pandemic forced people to change their mobility habits, with the reduction of non-essential travels and the promotion online activities. During the first phase of the emergency in 2020, governments considered several mobility restrictions to avoid the pandemic diffusion. However, it is difficult to quantify the actual effects of these restrictions on the virus spreading, especially due to the biased data available.

A novel methodology for epidemic risk assessment of COVID-19 outbreak.

We propose a novel data-driven framework for assessing the a-priori epidemic risk of a geographical area and for identifying high-risk areas within a country. Our risk index is evaluated as a function of three different components: the hazard of the disease, the exposure of the area and the vulnerability of its inhabitants. As an application, we discuss the case of COVID-19 outbreak in Italy.

In vitro evaluation of the antioxidant activity and biomembrane interaction of the lazaroid U-74389G.

The aim of this paper was to clarify whether the interaction of the lazaroid U-74389G with phospholipid membranes might be relevant as to its antioxidant activity. Thus we evaluated the "in vitro" antioxidant activity of U-74389G in two experimental models: 1) bleaching of the stable 1,1-diphenyl-2-picrylhydrazyl radical; 2) peroxidation, induced by the water-soluble radical initiator 2,2'-azobis(2-amidino-propane) hydrochloride, on mixed dipalmitoyl-phosphatidylcholine/linoleic acid unilamellar vesicles. Moreover, given that biophysical techniques may help in explaining the role of a drug in its interaction with the microenvironment of the model lipid membranes, we used a classical approach to investigate the U-74389G/model membrane interaction: the differential scanning calorimetry technique on dimyristoylphosphatidylcholine multilamellar and unilamellar vesicles and the Langmuir-Blodgett technique on dimyristoylphosphatidylcholine monolayers.