Publications by authors named "N Gimeno Clemente"
Role of Age, Comorbidity, and Frailty in the Prediction of Postoperative Complications After Surgery for Vulvar Cancer: A Retrospective Cohort Study with the Development of a Nomogram.
Curr Oncol
December 2024
Surgery is the cornerstone of vulvar cancer treatment, but it is associated with a significant risk of complications that may impact prognosis, particularly in older patients with multiple comorbidities. The objective of this study was to evaluate the role of age, comorbidities, and frailty in predicting postoperative complications after vulvar cancer surgery and to develop a predictive nomogram. A retrospective cohort study was conducted, including patients who underwent surgery for vulvar cancer at two Italian institutions from January 2018 to December 2023.
View Article and Find Full Text PDFBackground: Migrant women who are pregnant or postpartum and their infants are often at increased risk of poorer perinatal outcomes compared to host country populations. This review aimed to identify public health, policy, and clinical interventions to improve maternity care for migrant women and their infants in high-income countries (HICs).
Methods: In this systematic review we searched EMBASE, EMCARE, MEDLINE and PsycINFO, CENTRAL, Scopus, CINAHL Plus, Web of Science, and grey literature from inception to 13th March 2024, with no language or date restrictions (PROSPERO: CRD42022380678).
Article Synopsis
- - Tumour angiogenesis is crucial for supplying malignant cells with oxygen and nutrients, facilitating their invasion and spread, often resulting in the formation of disorganized and leaky blood vessels due to cytokine activity.
- - Nicotinamide phosphoribosyltransferase (eNAMPT) is elevated in many cancers, acting not only as a necessary enzyme for energy production but also as a pro-inflammatory cytokine that correlates with cancer aggressiveness and prognosis, especially in breast cancer.
- - In triple-negative breast cancer, eNAMPT promotes angiogenesis and metastasis by attracting NG2 pericytes and activating pro-inflammatory signaling, with potential therapeutic effects demonstrated by neutralizing eNAMPT with an antibody, pointing towards new anti-
Background/objectives: Methyltransferase EZH2-mediated H3K27me3 is involved in liver inflammation and fibrosis, but its role in hepatic metabolic derangements is not yet clearly defined. We investigated if a high-fat diet (HFD) induced early changes in EZH2 expression and H3K27 me3 in the liver of mice.
Methods: Five-week-old mice were fed an HFD or a low-fat diet (Control) for 2 weeks (2 W) or 8 weeks (8 W).