Monotherapy or combination therapy of Oleanolic acid? From therapeutic significance and drug delivery to clinical studies: A comprehensive review.

Oleanolic acid (OA) is a pentacyclic triterpenoid molecule widely distributed throughout medicinal plants. This naturally occurring OA has attracted considerable interest due to its wide range of pharmacological characteristics, notably its cytotoxic effects on various human cancer cell lines, making it a potential candidate for extensive therapeutic uses. In vivo studies have shown that OA possesses hepatoprotective, cardioprotective, anti-inflammatory and anti-microbial properties.

Ileal Pouch-Anal Anastomosis for Ulcerative Colitis: Predictors of Early and Late Complications.

Background Restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) is often considered the preferred surgical treatment for ulcerative colitis. This study was conducted to investigate the early and late complications of ileal pouch-anal anastomosis in patients with ulcerative colitis, as well as the factors associated with these complications. Methodology All relevant clinical and operative data of patients (n = 101) who underwent IPAA for ulcerative colitis between January 1995 and December 2018 were retrieved from a prospectively maintained database.

Mixed-species Pseudomonas biofilms: a novel and sustainable strategy for malachite green dye decolorization and detoxification.

This study investigated the application of mixed biofilms formed by two Pseudomonas strains (NAA22 and NAA23) for bio-decolorization of malachite green (MG) dye. The isolated strains displayed biofilm formation and MG decolorization capabilities. Mixed biofilms exhibited significantly greater biofilm formation and MG decolorization (94.