Publications by authors named "N Ghoniem"
Molecularly Imprinted Polymers (MIPs) are synthetic materials designed to selectively recognize and bind to specific target molecules. The process of determining Bupropion (BUP) using MIPs involves preparing the MIP, extracting the target molecule, and conducting subsequent analysis. A bio-inspired MIP-based electrochemical sensor was developed to detect BUP, utilizing the specific binding of MIPs to Bupropion molecules, enabling precise and sensitive detection.
View Article and Find Full Text PDFArticle Synopsis
- - COVID-19 has emerged as a significant global health issue, with about 10-15% of infected individuals experiencing post-COVID-19 syndrome that can result in ongoing symptoms like fatigue, breathlessness, and cognitive issues that may impact their quality of life.
- - To address these symptoms, treatments like Paracetamol and Dexketoprofen Trometamol are used for pain relief, while Rivaroxaban is prescribed to prevent blood clots for several weeks post-discharge.
- - A new eco-friendly method, utilizing HPLC-DAD technology, was developed to simultaneously measure these medications, showing effective and reliable results for both bulk and plasma samples according to international standards.
Indacaterol, a β agonist prescribed for long-term management of patients with chronic obstructive pulmonary disease and asthma. In this study the first MISPE cartridges was developed using indacaterol as a template for its selective extraction from rat lung tissues, enabling precise pharmacokinetic evaluation at the drug's site of action. A molecular imprinting polymer was synthesized using indacaterol as a template, methacrylic acid as a functional monomer and ethylene glycol dimethacrylate as a cross-linker with a molar ratio (1: 4: 20).
View Article and Find Full Text PDFA selective, precise, and accurate reversed HPLC method has been developed and validated for simultaneous separation and determination of two veterinary drugs, dipyrone and hyoscine, in their combined dosage form in the presence of their official impurities, namely 4-aminoantipyrine and tropic acid, in addition to the formulated preservative: phenol. The linearity range was found to be (1.00-35.
View Article and Find Full Text PDFArticle Synopsis
- Vilanterol is a daily inhaler for asthma and chronic obstructive pulmonary disease, and a study tested its stability under various stress conditions, finding it stable under heat and light but prone to degradation in acidic, basic, and oxidative environments.
- A UPLC method was developed to analyze vilanterol and its breakdown products, confirming the degradation followed first-order kinetics and met accuracy standards for drug quantification in urine.
- The study also noted that vilanterol and its metabolites are banned by the World Anti-Doping Agency in athletics, and the research followed ethical guidelines for human urine sample collection and testing.