Treatment of Plaque-Type Psoriasis With Oral CF101: Data from a Phase II/III Multicenter, Randomized, Controlled Trial.

Background: CF101, an adenosine A3 receptor agonist, is an orally bioavailable small molecule drug presenting an anti-psoriatic effect demonstrated in a Phase 2 clinical trial in psoriasis patients.


Objective: To evaluate the safety and efficacy of CF101 treatment in a Phase 2/3 study in patients with moderate to severe plaque-type psoriasis.


Methods: This multicenter, double-blind, 2-segment, placebo-controlled study randomized subjects with moderate to severe plaque psoriasis to CF101 1 or 2 mg, or placebo twice daily.

Sn-doped hydroxylated MgF₂ catalysts for the fast and selective saccharification of cellulose to glucose.

TIN, TAILORED, NOT SOLDER, BUT CAT: Doped hydroxylated fluorides, prepared by a modified sol-gel method, offer enhanced acidity and improved stability against water, and efficiency in the degradation of cellulose. These materials extend the portfolio of acid catalysts for fast and selective hydrolysis of biomass to glucose, which offers a feedstock for bioethanol production.

Involvement of cyan and ester groups in surface interactions of aerosil-cyanophenyl alkyl benzoate systems with high silica density: Infrared investigations.

Composites prepared from aerosil A380 and liquid crystals (LCs) of 4-n-alkyl-4'-cyanophenyl benzoate type, with four to six carbon atoms in the alkyl chain were investigated by infrared spectroscopy. Their high silica content (of 2-7 g aerosil/1 g of LC) was given by thermogravimetric investigations and allows the observation of a rather thin LC layer on the silica particles. Several surface species onto the external surface of the grains were demonstrated.

Phospholipid variation in acute ethanol intoxication in rats.

The effects of acute ethanol intoxication in different rat organs were studied with 32P. Since 32P incorporation in all compounds of cell membrane formation faithfully illustrate their structural and functional integrity, levels of 32P labelled phospholipids, from different organs were investigated in acute experiments. Researches were carried out on male rats, by administering doses of 3.