Publications by authors named "N Gheldof"
Postprandial hyperglycemia is an important risk factor in the development and progression of type-2 diabetes and cardiometabolic diseases. Therefore, maintaining a low postprandial glucose response is key in preventing these diseases. Carbohydrate-rich meals are the main drivers of excessive glycemic excursions during the day.
View Article and Find Full Text PDFProteomics reveals unique plasma signatures in constitutional thinness.
Proteomics Clin Appl
September 2022
Purpose: Studying the plasma proteome of control versus constitutionally thin (CT) individuals, exposed to overfeeding, may give insights into weight-gain management, providing relevant information to the clinical entity of weight-gain resistant CT, and discovering new markers for the condition.
Experimental Design: Untargeted protein relative quantification of 63 CT and normal-weight individuals was obtained in blood plasma at baseline, during and after an overfeeding challenge using mass spectrometry-based proteomics.
Results: The plasma proteome of CT subjects presented limited specificity with respect to controls at baseline.
Article Synopsis
- There is significant variability among individuals in gaining weight, even in similar environments, prompting research into genetic factors influencing obesity.
- A genome-wide association study (GWAS) identified anaplastic lymphoma kinase (ALK) as a potential gene linked to thinness in a specific group of metabolically healthy individuals with low BMI.
- Experiments in fruit flies and mice revealed that reducing ALK leads to lower fat storage and a resistance to obesity, suggesting that ALK plays a key role in regulating energy expenditure and fat breakdown.
Background: Constitutional thinness (CT), a non-malnourished underweight state with no eating disorders, is characterized by weight gain resistance to high fat diet. Data issued from muscle biopsies suggested blunted anabolic mechanisms in free-living state. Weight and metabolic responses to protein caloric supplementation has not been yet explored in CT.
View Article and Find Full Text PDFBackground: Constitutional thinness (CT) is a state of low but stable body weight (BMI ≤18 kg/m2). CT subjects have normal-range hormonal profiles and food intake but exhibit resistance to weight gain despite living in the modern world's obesogenic environment.
Objective: The goal of this study is to identify molecular mechanisms underlying this protective phenotype against weight gain.