Publications by authors named "N Galeotti"
Article Synopsis
- Microglia, the immune cells in the brain, contribute to neuroinflammation and aging, both of which increase the risk of neurodegenerative disorders like Alzheimer's disease (AD).
- This study examines the effects of Honokiol (HNK), a natural compound, and its synthetic version, Honokiol Hexafluoro (CH), on reducing inflammation and cellular aging in microglia cells.
- Results show that both HNK and CH effectively reduce harmful inflammation, improve anti-inflammatory responses, and inhibit markers of cellular senescence, suggesting their potential as therapeutic agents in treating age-related neurodegenerative diseases.
Epidemiological data indicate a strong association between alcohol use disorder (AUD) and neuropathic pain. Genetically-selected Marchigian Sardinian alcohol-preferring (msP) rats exhibit a high preference for alcohol compared with their background strain (Wistar rats), but their sensitivity to mechanical allodynia after chronic alcohol exposure is unknown. The present study compared the development of mechanical allodynia between "low, non-pathological drinker" Wistar rats and "high drinker" msP rats using the two-bottle choice (2BC) free-access procedure.
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- The gut microbiota-brain axis connects gut health to brain function, potentially influencing neurodegenerative diseases, particularly multiple sclerosis (MS).
- MS is characterized by gastrointestinal issues and an altered gut microbiome compared to healthy individuals, which may worsen disease symptoms and progression.
- The review discusses various dietary and microbiota-based interventions aimed at restoring gut health, which could help prevent or manage MS through symptom relief and slowing disease progression.
A large portion of neuropathic pain suffering patients may also concurrently experience neuropathic itch, with a negative impact on the quality of life. The limited understanding of neuropathic itch and the low efficacy of current anti-itch therapies dictate the urgent need of a better comprehension of molecular mechanisms involved and development of relevant animal models. This study was aimed to characterize the itching phenotype in a model of trauma-induced peripheral neuropathy, the spared nerve injury (SNI), and the molecular events underlying the overlap with the nociceptive behavior.
View Article and Find Full Text PDFNovel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo.
ACS Chem Neurosci
March 2024
Alzheimer's disease (AD) is a neurodegenerative form of dementia characterized by the loss of synapses and a progressive decline in cognitive abilities. Among current treatments for AD, acetylcholinesterase (AChE) inhibitors have efficacy limited to symptom relief, with significant side effects and poor compliance. Pharmacological agents that modulate the activity of type-2 cannabinoid receptors (CB2R) of the endocannabinoid system by activating or blocking them have also been shown to be effective against neuroinflammation.
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