Publications by authors named "N Gaia"
Background: Critical illness is associated with an altered gut microbiota, yet its association with poor outcomes remains unclear. This study evaluates the early gut microbiota diversity changes in intensive care unit patients and its association with mortality. Additionally, it explores fecal pH as a potential biomarker for these changes.
View Article and Find Full Text PDFIntroduction: The gut barrier, comprising gut microbiota, plays a pivotal role in chronic kidney disease (CKD) progression and nutritional status. This study aimed to explore gut barrier alterations in hemodialyzed (HD) patients, non-HD (NHD) CKD patients, and healthy volunteers.
Methods: Our cross-sectional study enrolled 22 HD patients, 11 NHD patients, and 11 healthy volunteers.
Article Synopsis
- Influenza A virus infection activates the NLRP3 inflammasome, leading to the release of the proinflammatory cytokine IL-1β from immune cells, which contributes to inflammation and fever.
- The contemporary PB1-F2 protein from certain IAV strains inhibits NLRP3 activation via a specific four-amino acid motif (TQGS) that affects the binding and localization of PB1-F2.
- Phylogenetic analysis indicates that this NLRP3 inhibitory motif is conserved across recent human-infecting IAV strains, providing insight into the molecular mechanisms of immune evasion by the virus.
We describe the inter-regional spread of a novel ESBL-producing subclone (ST131H89) in long-term care facility residents, general population, and environmental water sources in Western Switzerland between 2017 and 2020. The study highlights the importance of molecular surveillance for tracking emerging antibiotic-resistant pathogens in healthcare and community settings.
View Article and Find Full Text PDFArticle Synopsis
- Before using metagenomic next-generation sequencing (mNGS) in labs, researchers need to tackle some challenges related to detecting and quantifying bacteria in samples with a lot of host DNA.
- In this study, they tested different DNA extraction methods on pig muscle tissue spiked with various bacteria to see how well these methods worked.
- They found that while unenriched samples could quantify bacteria well, they struggled with sensitivity; however, using a modified enrichment procedure significantly improved bacterial detection and provided clearer taxonomic profiles.