Publications by authors named "N Gagliano"
The pandemic of coronavirus disease 19 (COVID-19), caused by severe respiratory syndrome coronavirus 2 (SARS-CoV-2), had severe repercussions for breast cancer patients. Increasing evidence indicates that SARS-CoV-2 infection may directly impact breast cancer biology, but the effects of SARS-CoV-2 on breast tumor cells are still unknown. Here, we analyzed the molecular events occurring in the MCF7, MDA-MB-231 and HCC1937 breast cancer cell lines, representative of the luminal A, basal B/claudin-low and basal A subtypes, respectively, upon SARS-CoV-2 infection.
View Article and Find Full Text PDFMolecular Analysis of Peri-implant Soft Tissue Response to Different Abutment Materials in Humans: A Pilot Study.
Int J Oral Maxillofac Implants
December 2024
Purpose: To evaluate the response of human peri-implant soft tissue (PIST) to different healing abutment materials 24 hours after positioning by assessing the expression of genes related to the early connective tissue wound healing response.
Materials And Methods: The following four materials were used to create experimental abutments that were mounted on implants placed in five patients (four different abutments in each patient): group A-grade 4 titanium (Ti), group B-grade 5 Ti, group C-zirconia (Zr), and group D-polyetheretherketone (PEEK). Before implant placement, a gingival biopsy (control, CT) sample was obtained using a 2-mm-diameter punch (T0).
Article Synopsis
- - Cigarette smoke (CS) negatively impacts lung cancer progression and patient outcomes, with current research focusing on how it affects macrophage behavior in the lungs of smokers.
- - The study used murine macrophages and cigarette smoke extract (CSE) to show that CS promotes polarization of macrophages towards an M2 phenotype, which are known to be more resistant to the harmful effects of CS.
- - The results suggest that CS encourages a predominance of M2 macrophages in the lungs of smokers, creating an anti-inflammatory and potentially immunosuppressive environment that worsens lung cancer conditions.
Melanoma is characterized by high metastatic potential favored by the epithelial-to-mesenchymal transition (EMT), leading melanoma cells to exhibit a spectrum of typical EMT markers. This study aimed to analyze the expression of EMT markers in A375 and BLM melanoma cell lines cultured in 2D monolayers and 3D spheroids using morphological and molecular methods. The expression of EMT markers was strongly affected by 3D arrangement and revealed a hybrid phenotype for the two cell lines.
View Article and Find Full Text PDFArticle Synopsis
- Hyaluronic acid (HA) is crucial for tissue repair and has been shown to improve wound healing in lab and animal studies, but there's a lack of human research specifically on oral soft tissue repair.
- This clinical trial involved eight patients where gingival biopsies were taken after surgery; one side received HA treatment, while the other did not, allowing for direct comparison.
- Results showed that HA treatment significantly improved early wound healing scores, increased levels of certain proteins and gene expressions related to collagen remodeling, but did not affect blood vessel growth in the tissues.