[The role of the thrombocyte and erythrocyte components of hemostasis in the development of thrombohemorrhagic complications in patients with systemic lupus erythematosus].

The authors evaluated changes of plasma, thrombocytic and erythrocytic links of hemostasis in 15 patients with thrombotic and in 30 with hemorrhagic complications in lupoid nephritis. Marked changes of thrombocytes, erythrocytes were caused by autoimmune processes with signs of thrombohemorrhagic syndrome requiring therapeutic correction using heparin and deaggregants under careful coagulographic control.

[The thrombocyte link in blood-coagulation homeostasis in patients with systemic lupus erythematosus].

Data are reported of changes of the thrombocytic link of hemostasis in 168 patients with systemic lupus erythematosus. Essential changes were found of the coagulating and fibrinolytic properties of thrombocytes, the severity of which is related to the activity of the pathological process. It is shown that thrombocytopathic changes may be adjunctive criteria for determination of the intravascular coagulopathy.

[The anticoagulant therapy of patients with dilated cardiomyopathy].

Complex treatment with direct and indirect anticoagulants and deaggregants carried out in 41 patients with dilated cardiomyopathy produces a significant positive effect on the condition of plasma hemostasis allowing to control the signs of hypercoagulation changes of the general coagulation, fibrinogen-like and antiheparin activity leading to normalization of fibrinolysis of the euglobulin plasma fraction. Prolonged intake of indirect anticoagulants furthers reduction of development of thromboembolism by 12.1%.

[Characteristics of blood coagulation changes in patients with dilated cardiomyopathy].

The main indices of the coagulogram, fibrinolysis and adhesive-aggregational properties of thrombocytes were evaluated in 40 patients with dilated cardiomyopathy with the purpose of determining the pathogenetic factors of thrombogenesis. Hypo- and hypercoagulation changes were found as well a reduction of the number of thrombocytes while the adhesiveness index remained unchanged; the aggregation and deaggregation capacities of thrombocytes reduced, the general fibrinolytic plasma activity increased.