[Trends in 25-year evolution of coronary atherosclerosis in males fom some cities of Europe and Asia].

Aim: Detection of changes in the course of coronary atherosclerosis (CA) which took place for 25 years of observation in male population in different cities.

Material And Methods: Epidemiological surveys of coronary AS by autopsy data according to WHO program were conducted in 1963-1966 (trial 1) and 1985-1989 (trial 2) in 9 cities: Ashkhabad (Turkmenistan), Bishkek (Kirghizia), Irkutsk, Yakutsk (Russia), Riga (Latvia), Tallinn, Tartu (Estonia), Kharkov, Yalta (Ukraine), Malme (Sweden), Prague (Czechia). The surveys enrolled males aged 20-59 years: 7470 males entered trial 1 and 9600 entered trial 2.

[Atherosclerosis in diabetes mellitus (repeated epidemiologic studies of atherosclerosis with an interval of 25 years)].

Repeated epidemiological studies of atherosclerosis were performed in 1985-1989 (as compared to 1965-1968) in 20-59-year-old males of malme, praha, Tallinn, Yalta and in 40-59-year-old females in Malme, Riga and Yalta. 358 cases of diabetes mellitus (DM) were studied. DM occurred more frequently during the second interval as compared to the first one: 6.

[Evolution of aortic atherosclerosis in specific European cities in the the 60's and 80's].

Repeated study of atherosclerosis epidemiology is performed in 5 European cities (Malme, Prague, Riga, Tallinn, Yalta) according to WHO recommendations 20 years after a similar study in the same regions. More frequent and more pronounced development of atherosclerosis in males of 20-39 years of age is found in the present study in 3 big cities (Prague, Riga, Tallinn) as compared to the population of small cities Malme and Yalta. The rejuvenation of atherosclerosis can not be explained by an ecological situation as in females atherosclerosis was most pronounced in Malme.

[Mitotic index as a prognostic factor in ductal breast cancer].

150 cases of infiltrating ductal mammary carcinoma with available 8-10 years follow-up data were studied to reveal correlations between mitotic index (MI), pathological mitosis index (PMI), survival after the mastectomy, primary tumor size, histology, degree of cell polymorphism and presence of axillary metastases. It was established that the prognostic value of MI and PMI, and their correlation with other prognostic factors is determined by the stage of tumour progression and histologic type of primary tumour. There is a significant negative correlation between MI, PMI, tumour size and survival in patients surviving maximum 8 years.