[Services for the elderly as a segment of the silver economy in the megalopolis: expert assessment. Part 2].

In the article, the authors continue to study the service sector for the elderly as a segment of the silver economy market. During the expert survey, services were identified that would be advisable to provide to older citizens. In particular, the block «information and innovation type services» is clearly identified.

Computational Study of Molecular Mechanism for the Involvement of Human Serum Albumin in the Renin-Angiotensin-Aldosterone System.

Human serum albumin (HSA) is an endogenous inhibitor of angiotensin I-converting enzyme (ACE) and, thus, plays a key role in the renin-angiotensin-aldosterone system (RAAS). However, little is known about the mechanism of interaction between these proteins, and the structure of the HSA-ACE complex has not yet been obtained experimentally. The purpose of the presented work is to apply computer modeling methods to study the interaction of HSA with ACE in order to obtain preliminary details about the mechanism of their interaction.

[Services for the elderly as a segment of the silver economy in the megalopolis: expert assessment. Part 1.].

The article examines the service sector for the elderly as a segment of the silver economy market. The author's classification of services provided to the elderly is given according to an expanded set of criteria. During the expert survey, medical and social services that are of primary demand among the elderly were identified.

Structure- and Cation-Dependent Mechanism of Interaction of Tricyclic Antidepressants with NMDA Receptor According to Molecular Modeling Data.

Some tricyclic antidepressants (TCAs), including amitriptyline (ATL), clomipramine (CLO), and desipramine (DES), are known to be effective for management of neuropathic pain. It was previously determined that ATL, CLO, and DES are capable of voltage-dependent blocking of NMDA receptors of glutamate (NMDAR), which play a key role in pathogenesis of neuropathic pain. Despite the similar structure of ATL, CLO, and DES, efficacy of their interaction with NMDAR varies significantly.