Publications by authors named "N G Sampat"
Objectives: Penile squamous cell carcinomas (PCs) are rare malignancies with a dismal prognosis in a metastatic setting; therefore, novel immunotherapeutic modalities are an unmet need. One such modality is the immune checkpoint molecule programmed cell death ligand 1 (PD-L1). We sought to analyze PD-L1 expression and its correlation with various clinicopathologic parameters in a contemporary cohort of 134 patients with PC.
View Article and Find Full Text PDFSpindle cell/sclerosing rhabdomyosarcoma is a rare neoplasm and has an aggressive clinical course. Because of its rarity, we performed a multi-institutional collaboration to comprehend the overarching clinical, histopathological, and immunohistochemical characteristics of a cohort of spindle cell/sclerosing rhabdomyosarcoma. Forty-five patients with spindle cell/sclerosing rhabdomyosarcoma were identified.
View Article and Find Full Text PDFPrimary renal synovial sarcoma is a rare aggressive mesenchymal neoplasm of the kidney that accounts for less than 1% of renal sarcomas. Herein, we describe the clinicopathologic and molecular findings of 14 renal synovial sarcoma patients in one of the largest case series to date and to our knowledge, the only renal synovial sarcoma series to use novel SS18-SSX IHC. Clinicopathologic, IHC, molecular, management, and follow-up data were reviewed and analyzed.
View Article and Find Full Text PDFLow-grade oncocytic tumour (LOT) of the kidney has recently emerged as a potential novel tumour type. Despite similarity to oncocytoma or eosinophilic chromophobe renal cell carcinoma, it shows diffuse keratin 7 immunohistochemistry (IHC) and negative KIT (CD117), which differs from both. We aimed to identify the molecular characteristics of these tumours.
View Article and Find Full Text PDFArticle Synopsis
- - The study focused on a rare form of solitary fibrous tumors (SFT) originating from the adrenal gland, involving nine patients, to investigate their demographics, clinical features, and follow-up data.
- - All tumors showed typical spindle cell characteristics, and most patients were categorized as low-risk for recurrence or metastasis after surgical treatment, with a follow-up showing no disease recurrence.
- - This research represents the largest collection of adrenal SFT cases to date, highlighting their generally benign nature and confirming the presence of specific markers like STAT6 in these tumors.