[Cytogenetic characteristics of H3 oxide induced myeloid leukemia in Wistar rats].

Frequency and spectrum of chromosomal aberrations were studied in hemopoietic cells of Wistar rats myeloid leukaemia induced by the prolonged exposure to tritium oxide. Differences in quantitative and structural damages of chromosomes were revealed by the cytogenetic assessment of eighteen rats with acute myeloid leukaemia (AML) and six rats with chronic myeloid leukaemia (CML). The most characteristic chromosomal aberrations for AML appeared to be rearrangements in chromosomes 1-3.

[The frequency of chromosome aberrations in rat bone marrow cells in the late period after a single uptake of tritium].

A prolonged self-maintenance of haemopoietic tissue cells with stable chromosome rearrangements following a single intake of tritium oxide in the amount of 24 MBq/g of body weight (absorbed dose of 11 Gy) is shown. Mutant cells revealed long after the radionuclide exposure are descendants of stem-cell precursors, bearing stable chromosome aberrations during the period of formation of radiation injury after the radionuclide administration.

[Structural chromosomal damages in myelokaryocytes exposed to plutonium-239 dioxide].

Plutonium 239 dioxide, with particle sizes of 1-2 micron, injected to Wistar rats intravenously in doses of 92.5, 46.3, and 23.

[Chromosome aberrations in hematopoietic stem cells in late periods after prolonged external irradiation].

At remote times following long-term external irradiation of Wistar rats with a cumulative dose of 10 Gy a 2-4-fold increase was registered in the spontaneous yield of chromosome aberrations in a population of original haemopoietic cells-precursors mainly due to symmetrical inter- and intrachromosomal exchanges.