Publications by authors named "N G Mishieva"
Article Synopsis
- - GnRHa triggering during fresh embryo transfers can lead to worse clinical outcomes due to luteal phase insufficiency, so this study analyzed 153 patients to compare different triggering methods and their hormonal impacts.
- - Group I received GnRHa + hCG support, Group II had a dual trigger (GnRHa + hCG), and Group III (control) was given 10,000 IU hCG; progesterone levels were notably lower in Groups I and II compared to Group III, but no significant differences in pregnancy outcomes were observed.
- - Pregnant women exhibited higher estradiol and progesterone levels on the day of the pregnancy test, while moderate ovarian hyperstimulation syndrome (OHSS) cases were noted in
Article Synopsis
- Antral follicle growth and recruitment play a crucial role in female reproduction, guided by the follicular wave theory which details how follicles develop and are selected over time.
- The article discusses the patterns of follicular waves across different life stages, including before puberty, during pregnancy, and perimenopause, supported by clinical and animal studies.
- Advances in understanding follicular dynamics have led to new ovarian stimulation techniques, such as luteal phase and double stimulation, which are beneficial for fertility preservation in cancer patients and improving the success rates of IVF for those with poor response.
Article Synopsis
- The study investigates the possibility of maturing oocytes from oophorectomy samples in patients with malignant ovarian tumors as a way to preserve fertility, especially in the context of oncofertility.
- A total of 27 patients were included, revealing that 99 cumulus-oocyte complexes were collected from 17 patients and resulted in a maturation rate of about 40%, with some oocytes being successfully vitrified for future use.
- It is concluded that this method may be beneficial for younger patients with specific health conditions before undergoing surgery or chemotherapy, highlighting the importance of AMH levels and tumor burden in the decision-making process.
Problem: Interleukin 8 (IL-8), vascular endothelial growth factor A (VEGFA), its receptors 1 (VEGFR1) and 2 (VEGFR2) are associated with ovarian hyperstimulation syndrome (OHSS) pathophysiological mechanisms. The aim of this study was to evaluate the concentrations of these cytokines depending on the way of ovulation triggering.
Method Of Study: A total of 51 high-responder patients underwent IVF program and received gonadotropin-releasing hormone agonists (GnRHa) trigger + 1500 IU human chorionic gonadotropin (hCG) support on the oocyte pick-up (OPU) day (group I), dual trigger (GnRHa + 1500 IU hCG; group II), or hCG trigger 10,000 IU (group III) for the final oocyte maturation.
Research Question: Does double stimulation (DuoStim) affect cumulus cell gene expression in luteal-phase-derived oocytes?
Design: This prospective observational study included 39 patients with reduced ovarian reserve. Fifteen patients (group 1) underwent IVF with a gonadotrophin-releasing hormone antagonist in the follicular phase and 24 patients (group 2) underwent DuoStim. A total of 149 cumulus cell samples were divided into two groups according to the phase of the cycle: group 1 included 55 follicular-phase-derived oocytes and group 2 included 94 luteal-phase-derived oocytes.