Publications by authors named "N G McKay"
Introduction: Chronic kidney disease (CKD) is associated with an increased risk of cognitive impairment. This cognitive impairment is associated with an increased permeability of blood-brain barrier (BBB) in rodents with CKD, linked to activation of aryl hydrocarbon receptor (AhR) by indoxyl sulphate (IS). The objective of the BREIN study was to confirm the increased BBB permeability in humans with CKD.
View Article and Find Full Text PDFThe "4.2 ka event" is a commonly described abrupt climate excursion that occurred about 4200 years ago. However, the extent to which this event is coherent across regional and larger scales is unclear.
View Article and Find Full Text PDFAcute stressors tend to shift preferences toward comfort foods, yet they do not ubiquitously increase the amount of food consumed. Moreover, although many individuals eat more under stress, others eat less or show no change. Although the precise mechanisms explaining this variability in stress-related eating are unknown, they may be driven by individual differences in the rewarding effects of comfort eating, which are enhanced by greater lifetime stressor exposure.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates early Alzheimer's disease changes in the brains of people with Down syndrome and those with genetic variants linked to Alzheimer's, aiming to better understand disease development and improve prevention strategies.
- Using cross-sectional data from two cohort studies, researchers analyzed tau protein spread and its relationship with amyloid accumulation in participants aged 25 and older.
- Findings revealed significant differences in the pattern and timing of tau accumulation in the two groups, suggesting implications for early intervention and clinical trials targeting Alzheimer's pathology.
Objective: We aimed to illustrate how complex cognitive data can be used to create domain-specific and general cognitive composites relevant to Alzheimer disease research.
Method: Using equipercentile equating, we combined data from the Charles F. and Joanne Knight Alzheimer Disease Research Center that spanned multiple iterations of the Uniform Data Set.