Publications by authors named "N G Koulouris"
Background: Reticulation, ground glass opacities and post-infection bronchiectasis are present three months following hospitalisation in patients recovering from SARS-CoV-2 infection and are associated with the severity of acute infection. However, scarce data exist on small airways impairment and lung hyperinflation in patients with long COVID-19.
Aim: To evaluate small airways function and lung hyperinflation in previously hospitalised patients with long COVID-19 and their association with post-COVID-19 breathlessness.
Article Synopsis
- - The study investigates how a 3-month cardiopulmonary rehabilitation program affects heart health and blood vessel stiffness in people recovering from COVID-19, comparing them to a non-COVID-19 group.
- - Results show significant improvements in arterial stiffness (PWV) and left ventricular function in the COVID-19 group who participated in rehabilitation, while these measures remained poor in those who didn't.
- - The findings suggest that rehabilitation effectively enhances recovery in heart-related metrics and overall physical fitness in post-COVID-19 patients, emphasizing the importance of such programs after the illness.
Article Synopsis
- Long COVID-19 syndrome is linked to cardiorespiratory issues, but its effect on exercise capacity is still unclear, leading researchers to study this relationship using cardiopulmonary exercise testing (CPET) and echocardiograms.
- The study involved 42 patients recovering from COVID-19 and 10 healthy participants, assessing heart function through various measures such as left ventricular ejection fraction (LVEF) and pulmonary artery pressure.
- Results showed that patients had significantly lower heart function and exercise capacity compared to healthy participants, with exercise intolerance being associated with left ventricular performance and pressures, indicating that heart health is crucial for recovery in long COVID-19.
Article Synopsis
- The study aimed to gather real-world data on the EGFR mutational profile and treatment strategies for advanced non-small-cell lung cancer (NSCLC) patients after first/second-generation EGFR-TKI treatment.
- Ninety-six patients were enrolled in Greece, with re-biopsies conducted for some who were negative for the T790M mutation.
- Results showed that 21.9% of patients were T790M-positive, and those receiving third-generation EGFR-TKIs had better outcomes, highlighting the importance of mutational status and treatment choices in improving response rates and progression-free survival.