Publications by authors named "N G Knox"
Evidence suggests that the gut microbiome may play a role in multiple sclerosis (MS). However, the majority of the studies have focused on gut bacterial communities; none have examined the fungal microbiota (mycobiota) in persons with pediatric-onset multiple sclerosis (POMS). We examined the gut mycobiota in persons with and without POMS through a cross-sectional examination of the gut mycobiota from 46 participants' stool samples (three groups: 18 POMS, 13 acquired monophasic demyelinating syndromes [monoADS], and 15 unaffected controls).
View Article and Find Full Text PDFThe incorporation of sequencing technologies in frontline and public health healthcare settings was vital in developing virus surveillance programs during the Coronavirus Disease 2019 (COVID-19) pandemic caused by transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, increased data acquisition poses challenges for both rapid and accurate analyses. To overcome these hurdles, we developed the SARS-CoV-2 Illumina GeNome Assembly Line (SIGNAL) for quick bulk analyses of Illumina short-read sequencing data.
View Article and Find Full Text PDFIntroduction: Unmet needs in the older population with cancer are complex due to aging-related health conditions. A review of unmet needs in older people with cancer showed that needs varied among different cancer types. In lung cancer, a higher incidence of geriatric syndromes and comorbidities exist compared to other cancer cohorts, impacting treatment tolerance and completion.
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- - Menopause leads to reduced ovarian hormone production, increasing cisgender women's risks for obesity, cognitive decline, and mood disorders, particularly under chronic stress conditions.
- - In a mouse study, researchers examined the effects of a high-fat diet (HFD) alongside chronic stress after inducing menopause-like conditions using a chemical called VCD, which depletes ovarian function.
- - Results showed that mice on HFD had higher body fat and glucose levels, coupled with worse cognitive and anxiety-related behaviors, indicating potential dietary influences on the negative effects of menopause-related estrogen deficiency.
Article Synopsis
- - Wastewater surveillance has proven effective in tracking the spread of SARS-CoV-2, including its variants, particularly at transportation hubs like Toronto Pearson International Airport.
- - Canadian municipalities, including WWTPs in Ontario, use techniques like qPCR and whole genome sequencing to monitor the virus in wastewater.
- - Findings from wastewater samples at the airport often identified new viral lineages 1-4 weeks before clinical cases were reported, highlighting the potential for early detection in pandemic response.