Publications by authors named "N G Klimas"
Treatment fidelity, or consistent therapist adherence and competence in intervention delivery, is an important component of intervention design and dissemination. Yet, few systems have been developed to assess fidelity in telepsychology and related remotely-delivered intervention venues. We sought to modify and evaluate a fidelity coding approach for a videoconference-delivered group Cognitive Behavioral Stress Management (CBSM) intervention.
View Article and Find Full Text PDFIntroduction: Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) experience cognitive problems with attention, information processing speed, working memory, learning efficiency, and executive function. Commonly, patients report worsening of cognitive symptoms over time after physical and/or cognitive challenges. To determine, monitor, and manage longitudinal decrements in cognitive function after such exposures, it is important to be able to screen for cognitive dysfunction and changes over time in clinic and also remotely at home.
View Article and Find Full Text PDFArticle Synopsis
- - The neurovascular unit (NVU) inflammation from glial cell activation and neuronal damage significantly contributes to neurodegenerative diseases, though the exact disease mechanisms are not fully understood.
- - Biomarkers like neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) can indicate the severity, progression, and treatment response in various brain disorders by assessing brain cell health and blood-brain barrier integrity.
- - Chronic inflammation is prevalent in age-related neurodegenerative diseases such as Alzheimer's and Parkinson's, and certain biomarkers may change years before disease onset, highlighting their potential for early detection and research into neurovascular pathologies.
Article Synopsis
- * The study analyzed data from 923 participants, revealing that chronic migraines (48.1%), fibromyalgia (45.0%), and chronic low back pain (33.1%) were the most common COPCs among those with ME/CFS.
- * The presence of COPCs significantly worsens health outcomes for ME/CFS patients, particularly affecting pain-related symptoms, with fibromyalgia showing the highest prevalence ratio and effect size.*
Objective: Long COVID is a major health concern because many patients develop chronic neuropsychiatric symptoms, but the precise pathogenesis is unknown. Matrix metalloproteinase-9 (MMP-9) can disrupt neuronal connectivity and be elevated in patients with long COVID.
Methods: In this study, MMP-9 was measured in the serum of long COVID patients and healthy controls, as well as in the supernatant fluid of cultured human microglia cell line stimulated by recombinant severe acute respiratory syndrome coronavirus 2 Spike protein, as well as lipopolysaccharide (LPS) and neurotensin (NT) used as positive controls.