[The synthetic cannabinoid analog WIN 55,212-2 potentiates the amplitudes of glycine-activated currents].

Most of the pharmacological actions of cannabinoids are mediated by CB1 receptors. There is also evidence that these compounds can produce effects that are not mediated by the activation of identified cannabinoid receptors. Our data demonstrate that cannabinoids may directly affect the functioning of inhibitory glycine receptor (GlyR) channels.

[The long-term results of surgical treatment of critical lower limb ischemia by autotransplantation using different tissues].

Presented herein is an analysis of the 15-year results of surgical treatment of critical lower limb ischemia (stage IV chronic ischemia according to Fontaine - Pokrovsky classification) in patients suffering from chronic occlusive diseases of lower lirtb arteries (CODLLA) with subtotal and total obliteration of the peripheral arterial system. In total lesion of the talotibial segment when the patients could not be rendered assistance using conventional vascular surgery or when roentgenoendovascular deobliterution was not feasible, use was made of indirect revascularizntion of the ischemized limb by autotransplantation of soft tissue complexes. A flap of the broadest muscle of back (FBMB) was employed as an autotransplant in 56 patients, the greater omentum in 12 patients, and a flap of the anterior dentate muscle (FADM) was used in 9 patients.