Publications by authors named "N Fujitsuka"
Article Synopsis
- Aquaporin 2 (AQP2) is essential for water reabsorption and urine concentration, and its localization in kidney cells is influenced by anti-diuretic hormones, making it a target for specific medications.
- This study looked at how Goreisan (GRS), a traditional Japanese herbal medicine, affects urine production and AQP2 levels in mice, particularly under conditions induced by desmopressin.
- Findings revealed that GRS enhances diuretic effects by temporarily raising calcium levels in cells and decreasing the accumulation of phosphorylated AQP2 at the kidney's luminal surface, thus helping to regulate urine volume.
Background: Rikkunshito (RKT), a traditional Japanese medicine, can relieve epigastric discomfort and anorexia in patients with functional dyspepsia. RKT enhances the orexigenic hormone, ghrelin. Ghrelin regulates food motivation by stimulating the appetite control center in the hypothalamus and the brain mesolimbic dopaminergic pathway (MDPW).
View Article and Find Full Text PDFEffect of the Japanese herbal medicine Hochuekkito for systemic inflammation, prognostic nutrition index, and body composition status in patients with gastrointestinal cancer.
Clin Nutr ESPEN
October 2024
Article Synopsis
- The study investigates the effects of Hochuekkito (TJ-41), a Japanese herbal medicine, on inflammation and nutritional status in cancer patients, particularly focusing on malnutrition and muscle loss (sarcopenia).
- Researchers analyzed 99 patients over 3 months, observing a significant reduction in the inflammatory marker C-reactive protein (CRP) in those with gastrointestinal cancer, especially in patients with metastatic disease.
- The findings suggest that TJ-41 could be beneficial as a complementary treatment for gastrointestinal cancer by potentially reducing inflammation and helping manage muscle loss.
Secondary lymphedema occurs after cancer surgery involving lymph node dissection owing to the lymphatic system dysfunction. However, the pathophysiology of lymphedema and the molecular pathways involved remain unknown. This study aimed to develop a rat hindlimb lymphedema model and investigate the mechanisms that drive pathophysiology and the effects of the traditional Japanese medicine goreisan on lymphedema.
View Article and Find Full Text PDFBackground: Polycystic ovary syndrome (PCOS) is a common disorder resulting in irregular menstruation and infertility due to improper follicular development and ovulation. PCOS pathogenesis is mediated by downregulated follicle-stimulating hormone receptor (FSHR) expression in granulosa cells (GCs); however, the underlying mechanism remains elusive. Unkeito (UKT) is a traditional Japanese medicine used to treat irregular menstruation in patients with PCOS.
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