Publications by authors named "N Franke"
In utero exposure to gestational diabetes mellitus (GDM) is associated with adverse long-term outcomes. Little is known about how mothers perceive these outcomes and the support they need for optimal outcomes for their children. We aimed to explore how women perceive the risk of adverse outcomes for their children exposed to GDM and the support they require for their optimal health.
View Article and Find Full Text PDFPost-traumatic stress, sleep, and neurocognitive problems in children newly diagnosed with a pediatric brain tumor.
J Clin Exp Neuropsychol
December 2024
Article Synopsis
- Children diagnosed with brain tumors often experience neurocognitive problems, and this study investigates the impacts of post-traumatic stress and sleep on their cognitive abilities.
- The research included 60 children aged 6-16, who completed questionnaires and neurocognitive tests 51 days after diagnosis, revealing they scored lower in attention, inhibition, and verbal memory compared to age norms.
- Findings suggest that factors like tumor location and early treatment affect cognitive functioning, but post-traumatic stress and sleep did not show a significant association at this early assessment stage.
Atypical teratoid/rhabdoid tumors (ATRTs) are highly malignant embryonal tumors of the central nervous system with a dismal prognosis. Using a newly developed and validated patient-derived ATRT culture and xenograft model, alongside a panel of primary ATRT models, we found that ATRTs are selectively sensitive to the nucleoside analog gemcitabine. Gene expression and protein analyses indicate that gemcitabine treatment causes the degradation of sirtuin 1 (SIRT1), resulting in cell death through activation of nuclear factor κB (NF-κB) and p53.
View Article and Find Full Text PDFObjective: To determine the relationship between transient neonatal hypoglycemia in at-risk infants and neurocognitive function at 6-7 years of corrected age.
Study Design: The pre-hPOD Study involved children born with at least 1 risk factor for neonatal hypoglycemia. Hypoglycemia was defined as ≥1 consecutive blood glucose concentrations <47 mg/dl (2.
High rates of academic underachievement at 9-10 years have been identified in children born at risk of neonatal hypoglycaemia. This study investigated the stability of behaviour from early to mid-childhood and how this relates to academic outcomes in children born with at least one risk factor of neonatal hypoglycaemia in Aotearoa, New Zealand. Behaviour data was collected using the Bayley Scales of Infant and Toddler Development, Child Behaviour Checklist 1.
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