Publications by authors named "N Fourcade"

Our study, based on microsimulation models, evaluates the redistributive impact of health care insurance in France on income distribution between age and social groups. This work sheds light on the debate concerning the respective role of the public health care insurance (PHI) and the private supplemental health care insurance (SHI) in France. The analysis points out that the PHI enables the lowest-income households and the pensioners a better access to health care than they would have had under a complete private SHI.

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The analysis of the literature demonstrated that pharmacy counselling influenced patient outcome after transplantation. This was the reason we established pharmacy consultation in 1999. The aim of this study was to determine patient knowledge before and after pharmacy counselling.

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The objective of this study was to estimate tacrolimus population parameter values and to evaluate the ability of the maximum a posteriori probability (MAP) Bayesian fitting procedure to predict tacrolimus blood levels, using the traditional strategy of monitoring only trough levels, for dosage individualization in liver transplant patients. Forty patients treated with tacrolimus after liver transplantation were studied during the early posttransplant phase (first 2 weeks). This phase was divided into four time periods (1-4 days, 5-7 days, 8-11 days, 12-14 days).

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Article Synopsis
  • A study used NPEM2 software to analyze cyclosporine pharmacokinetics in 25 liver transplant patients during the first week after surgery, focusing on population parameters like volume and elimination rate.
  • The findings indicated reasonable pharmacokinetic values and identified greater drug clearance immediately post-surgery, which gradually decreased over the following days.
  • Using Bayesian predictive methods, the study successfully predicted subsequent cyclosporine blood levels in 76% of patients, demonstrating the potential for real-time monitoring in managing drug regimens for liver transplant recipients.
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