Lifespan Normative Models of White Matter Fractional Anisotropy: Applications to Early Psychosis.

Unlabelled: This study presents large-scale normative models of white matter (WM) organization across the lifespan, using diffusion MRI data from over 25,000 healthy individuals aged 0-100 years. These models capture lifespan trajectories and inter-individual variation in fractional anisotropy (FA), a marker of white matter integrity. By addressing non-Gaussian data distributions, race, and site effects, the models offer reference baselines across diverse ages, ethnicities, and scanning conditions.

Linking functional and structural brain organisation with behaviour in healthy adults.

Multimodal data integration approaches, such as Linked Independent Component Analysis (LICA), increase sensitivity to brain-behaviour relationships and allow us to probe the relationship between modalities. Here we focus on inter-regional functional and structural organisation to determine if organisational patterns persist across modalities and if investigating multi-modality organisations provides increased sensitivity to brain-behaviour associations. We utilised multimodal magnetic resonance imaging (MRI; T1w, resting-state functional [fMRI] and diffusion weighted [DWI]) and behavioural data from the Human Connectome Project (HCP, n=676; 51% female).

Biosensor capability of the endometrium is mediated in part, by altered miRNA cargo from conceptus-derived extracellular vesicles.

We tested the hypothesis that the biosensor capability of the endometrium is mediated in part, by the effect of different cargo contained in the extracellular vesicles secreted by the conceptus during the peri-implantation period of pregnancy. We transferred Bos taurus taurus embryos of different origin, in vivo (high developmental potential (IV)), in vitro (intermediate developmental potential (IVF)), or cloned (low developmental potential (NT)), into Bos taurus indicus recipients. Extracellular vesicles (EVs) recovered from Day 16 conceptus-conditioned medium were characterized and their microRNA (miRNA) cargo sequenced alongside RNA sequencing of their respective endometria.