Anatomic Posterolateral Corner Reconstruction of the Knee Using Single Semitendinosus Autograft: Technical Note for the Borderline-length Graft.

The original LaPrade technique for anatomic reconstruction of the posterolateral corner of the knee uses two separate allografts. More recently, a modification of this technique, using an adjustable-length suspension device with a cortical button for tibial fixation, allows anatomic reconstruction with a single semitendinosus autograft. This modification is of utmost relevance when sources of allograft are not available for multiligament knee reconstruction.

Average direct cost of peripherally inserted central catheterization by nurses in hospitalized patients: a cost estimate.

Objective: This study aimed to estimate the direct costs of peripherally inserted central catheterization by nurses for hospitalized patients.

Methods: A cost estimation study using a quantitative approach was conducted in a public teaching hospital in northern Paraná to calculate the direct costs of peripherally inserted central catheterization. The population included all medical records of patients between 15 and 99 years of age who were hospitalized and underwent peripherally inserted central catheterization by nurses between January 1, 2019, and December 31, 2021, totaling 664 insertions.

Nose-to-Brain Delivery of Biomimetic Nanoparticles for Glioblastoma Targeted Therapy.

Glioblastoma (GBM) is an extremely aggressive form of brain cancer that remains challenging to treat, especially owing to the lack of effective targeting and drug delivery concerns. Due to its anatomical advantages, the nose-to-brain strategy is an interesting route for drug delivery. Nanoengineering has provided technological tools and innovative strategies to overcome biotechnological limitations, which is promising for improving the effectiveness of conventional therapies.

Influence of CReatine Supplementation on mUScle Mass and Strength After Stroke (ICaRUS Stroke Trial): A Randomized Controlled Trial.

Background/objectives: The acute phase of stroke is marked by inflammation and mobility changes that can compromise nutritional status. This study was a randomized, double-blind, placebo-controlled trial evaluating the effectiveness of creatine supplementation for older people during seven days of hospitalization for stroke compared to usual care.

Method: The primary outcome measures were changes in functional capacity, strength, muscle mass, and muscle degradation.

Acute Ecotoxicity and Bioconcentration Tests for Se(IV) in Nile tilapia ().

Selenium is one of the most important trace element micronutrients for the global biota, mainly due to its role in protecting against oxidative stress. However, this element can become toxic when present at concentrations slightly higher than those needed for metabolic purposes. It can be transferred through the food chain toward higher trophic levels, with bioaccumulation and biomagnification leading to possible toxicity.