Publications by authors named "N Fasel"

Copulatory behaviours stand as cornerstones of sexual selection, yet they remain mysterious in many species. Because of their nocturnal and elusive lifestyle, the copulatory behaviours of bats have been mostly overlooked. Several aspects of bat reproduction differ from other mammals (e.

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Article Synopsis
  • The lymphatic system is essential for the immune response against intracellular pathogens but also aids cancer cell spread, and its role in mucocutaneous leishmaniasis (MCL) has not been fully explored.
  • Recent findings show that in cases of MCL, particularly when inflammation and viral endosymbionts are present, lymphatic vessels help infected cells escape from the initial infection site and spread to other organs.
  • Researchers used various methods to verify that parasites can move through migrating immune cells and lymphatic systems, leading to new infections in distant areas, highlighting the complex pathways of parasite dissemination.
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Inducible nitric oxide synthase (iNOS) is essential to the production of nitric oxide (NO), an efficient effector molecule against intracellular human pathogens such as protozoan parasites. Some strains of are known to bear a viral endosymbiont termed RNA virus 1 (LRV1). Recognition of LRV1 by the innate immune sensor Toll-like receptor-3 (TLR3) leads to conditions worsening the disease severity in mice.

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RNA virus 1 (LRV1) is a double-stranded RNA virus found in some strains of the human protozoan parasite , the causative agent of leishmaniasis, a neglected tropical disease. Interestingly, the presence of LRV1 inside constitutes an important virulence factor that worsens the leishmaniasis outcome in a type I interferon (IFN)-dependent manner and contributes to treatment failure. Understanding how macrophages respond toward alone or in combination with LRV1 as well as the role that type I IFNs may play during infection is fundamental to oversee new therapeutic strategies.

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