Publications by authors named "N Farha"
Objectives: To predict and characterize the three-dimensional (3D) structure of protein arginine methyltransferase 2 (PRMT2) using homology modeling, besides, the identification of potent inhibitors for enhanced comprehension of the biological function of this protein arginine methyltransferase (PRMT) family protein in carcinogenesis.
Materials And Methods: An method was employed to predict and characterize the three-dimensional structure. The bulk of PRMTs in the PDB shares just a structurally conserved catalytic core domain.
The incidence of early-onset colorectal cancer (eoCRC) is rising, and its pathogenesis is not completely understood. We hypothesized that machine learning utilizing paired tissue microbiome and plasma metabolome features could uncover distinct host-microbiome associations between eoCRC and average-onset CRC (aoCRC). Individuals with stages I-IV CRC (n = 64) were categorized as eoCRC (age ≤ 50, n = 20) or aoCRC (age ≥ 60, n = 44).
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- The study evaluates the levels of organochlorine pesticides (OCPs) and polycyclic aromatic hydrocarbons (PAHs) in tissues of stranded sea snakes in Sharjah, UAE, analyzing samples from 13 individuals of three species.
- Muscle, liver, and fat tissues were processed using micro-QuEChERs and analyzed with gas chromatography-mass spectrometry (GC/MS), revealing that OCPs were present in higher concentrations while PAHs were detected more frequently.
- The findings indicate significant bioaccumulation of OCPs and PAHs in sea snake tissues, with variations in OCP types detected based on tissue type and higher concentrations of OCPs compared to previous studies in marine reptiles.