Pixantrone-rituximab versus gemcitabine-rituximab in relapsed/refractory aggressive non-Hodgkin lymphoma.

Unlabelled: We describe the rationale and design of the ongoing randomized, active-controlled, multicenter, Phase III study evaluating the efficacy of pixantrone and rituximab versus gemcitabine and rituximab in patients with diffuse large B-cell lymphoma or follicular grade 3 lymphoma, who are ineligible for high-dose chemotherapy and stem cell transplantation, and who failed front-line regimens containing rituximab. The administration schedule is pixantrone 50 mg/m(2) intravenously (iv.) or gemcitabine 1000 mg/m(2) iv.

Contribution of encapsulation on the biodisponibility of retinol.

To show the benefits of retinol encapsulation in cosmetic industry, we compared the diffusion of two different retinol preparations through skin:oil-in-water (o/w) emulsions of retinol, also called 'free retinol', and suspension of Cylasphere including retinol, also called 'encapsulated retinol'. Two methods were used: Franz cell elucidated retinol release and storage in a hairless mouse skin according to time for the two types of preparations. The dosage of retinol by high performance liquid chromatography (HPLC) showed that encapsulated retinol was maintained into the skin for a longer time than free retinol.

Quantitative analysis of vitamin A degradation by Raman spectroscopy.

Vitamin A is known to support cell growth promotion, maintenance, and differentiation of epithelial tissues. Retinol is currently used in cosmetic formulations and products to deliver these and other benefits to the skin. However, retinol is known to be unstable and, therefore, remains of great concern to the cosmetic industry.