Publications by authors named "N FRANK"
The deep Southern Ocean (SO) circulation plays a key role in the storage and release of CO in Earth's climate system. The uptake and release of CO strongly depend on the redistribution of well and poorly ventilated deep ocean water masses. Recently, evidence was found for possible stronger Pacific deep water overturning and subsequent intrusion into the SO during periods of reduced AMOC.
View Article and Find Full Text PDFNissl histology underpins our understanding of brain anatomy and architecture. Despite its importance, no high-resolution datasets are currently available in the literature for 14-day-old rats. To remedy this issue and demonstrate the utility of such a dataset, we have acquired over 2000 high-resolution images (0.
View Article and Find Full Text PDFBackground Aims: The need for large-scale production of mesenchymal stromal cell (MSC)-based cellular therapeutics continues to grow around the globe. Manual cell expansion processes can be highly variable between operators, require significant hands-on time from skilled staff and, because of the large number of open manipulation steps required to produce cells in dose-relevant quantities, be prone to greater risk of contamination relative to automated processes. All of these can increase overall production costs and risks to the patient.
View Article and Find Full Text PDFArticle Synopsis
- The development of antiviral drugs for SARS-CoV-2 is essential due to limited treatment options and the possibility of reinfection after vaccination.
- Two key viral targets for drug development are the 3'-5' exoribonuclease (ExoN) and the 2'-O-methyltransferase (2'-O-MTase), which are crucial for the virus's survival.
- The study utilizes target-directed dynamic combinatorial chemistry (tdDCC) to find compounds that inhibit the interactions of essential viral proteins, resulting in a new class of inhibitors that show antiviral activity against coronaviruses.
Purpose: Timely access to clinical genetics consultations remains a barrier to timely genomic medicine services, which new service delivery models might help address.
Methods: We implemented a genetics electronic consultation (eConsult) service staffed by a primary care physician (PCP) champion, supervised by genetics specialists. Chart reviews from July 2018 to January 2022 examined categories of questions received, e-consultant's recommendations, and outcomes of any conventional genetics referrals.