[Characteristics of PIK3CA gene mutations in Her2-low breast cancer].

Background: Mutations in the gene, encoding the catalytic subunit of the PI3K class IA p110α, is a common mechanism of activating of PI3K/AKT/mTOR pathway in breast cancer (BC). The detection of these mutations in patients with hormone-positive Her2-negative BC is of important clinical value, since they are the predictor of the sensitivity of the tumor to the PI3K inhibitor - alpelisib. According to the status of the Her2/neu expression, all patients with hormone-positive Her2-negative BC can be divided into two groups - with low expression of Her2/neu (IHC 1+; 2+, ISH-) and with a complete lack of expression of this protein (IHC 0).

An Open-Source Wireless Electrophysiological Complex for In Vivo Recording Neuronal Activity in the Rodent's Brain.

Multi-electrode arrays (MEAs) are a widely used tool for recording neuronal activity both in vitro/ex vivo and in vivo experiments. In the last decade, researchers have increasingly used MEAs on rodents in vivo. To increase the availability and usability of MEAs, we have created an open-source wireless electrophysiological complex.

Study and modeling of the distribution process of some phenolic compounds between the solid and liquid phases.

The article presents the results related to the study of distribution of biologically active substances from the plant raw material between solid and liquid phases. The aim of this study is to develop theoretical bases of the extraction process in the equilibrium state by the example of study and modeling of the distribution process of biologically active substances from leaves. In these studies, we used ground plant raw material of leaves with particle fraction of 0.

[The pathogenesis of the renal syndrome in hemorrhagic fever].

Lipid peroxidation was investigated in 89 patients suffering from hemorrhagic fever with renal syndrome. In addition to routine tests, measurements were made of plasma malonic dialdehyde and acyl hydroperoxides the levels of which were found increased 1.3-1.

[Lysozyme activity in diphyllobothriasis patients].

A considerable decrease in lysozime activity has been detected in the serum of patients with diphyllobothriasis especially in the early period of invasion. A 13-20-fold increase in enzyme activity has been found in the urine of patients, which disappeared 1 month after treatment, indicating the normalization of the immune status after the recovery from diphyllobothriasis. The index of lysozyme activity may be used in combination with other tests for the evaluation of the treatment efficacy.