Publications by authors named "N F Karakuyu"
Lacosamide (LCM) selectively increases the slow inactivation of voltage-gated sodium channels (VGSCs) and is a N-methyl D-aspartate acid (NMDA) receptor glycine site antagonist. Therefore, it can be used in dryness-related hyperexcitability of corneal cold receptor nerve terminals. Ocular in-situ gels remain in liquid form until they reach the target site, where they undergo a sol-gel transformation in response to specific stimuli.
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- * The study investigated the effects of salubrinal (SLB) and magnesium (Mg) on pregnant rats experiencing chorioamnionitis, dividing them into control and treatment groups.
- * Results showed that SLB and Mg treatments improved inflammatory and apoptotic markers in placental and fetal brain tissues, with the best outcomes in the combined treatment group, highlighting the need for further molecular research.
Objective: In the current research, 6-gingerol (GA)-loaded were developed, and their potential usage in wound healing was evaluated.
Significance: This study investigates the effectiveness of nanofibrous membranes composed of sodium alginate (SA), poly(vinyl alcohol) (PVA), and 6-gingerol (GA) as delivery systems for anti-inflammatory agents in the context of wound dressings.
Methods: GA-loaded SA/PVA nanofiber was prepared using electrospinning.
L-carnitine protects the lung from radiation-induced damage in rats via the AMPK/SIRT1/TGF-1ß pathway.
Naunyn Schmiedebergs Arch Pharmacol
October 2024
Article Synopsis
- * In the study, rats were divided into four groups to compare the outcomes of RAD treatment alone versus RAD plus LCAR, with results showing that LCAR mitigated damage like inflammation and oxidative stress in the lungs.
- * The protective effects of LCAR were linked to increased expression of beneficial genes (AMPK and SIRT1) and decreased harmful gene expression (TGF-1ß), suggesting it could serve as a supplement to alleviate complications from RAD treatment.
Purpose: The ischemia-reperfusion (I/R) injury seen in the heart can cause severe damage to essential organs such as the brain. Cannabidiol (CBD) obtained from Cannabis sativa is used today to treat various diseases. This study aimed to demonstrate CBD's neuroprotective and therapeutic properties in rats with brain damage caused by I/R in the heart.
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